In isolated guinea-pig heart submitted to hypoxia in the absence of substrate and subsequent reoxygenation 1-20 mM taurine decreases LDH release and ventricular arrhythmias, and the recovery of normal electrical and mechanical activity is increased. The taurine effect is dose-dependent, and is not mimicked by beta-alanine. Moreover, taurine reduces the increase in calcium gain of reoxygenated heart.
The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart / Franconi F; Stendardi I; Failli P; Matucci R; Baccaro C; Montorsi L; Bandinelli R; Giotti A. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - STAMPA. - 34:(1985), pp. 2611-2615.
The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart.
FRANCONI, FLAVIA;STENDARDI, ISABELLA;FAILLI, PAOLA;MATUCCI, ROSANNA;GIOTTI, ALBERTO
1985
Abstract
In isolated guinea-pig heart submitted to hypoxia in the absence of substrate and subsequent reoxygenation 1-20 mM taurine decreases LDH release and ventricular arrhythmias, and the recovery of normal electrical and mechanical activity is increased. The taurine effect is dose-dependent, and is not mimicked by beta-alanine. Moreover, taurine reduces the increase in calcium gain of reoxygenated heart.
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