Taurine increases the calcium levels in guinea-pig ventricular strips at external calcium concentrations of 0.45, 0.9 and 1.8 mM. At 2.7 mM calcium, however, a decrease is observed. Analogous changes occur in contractile force. It is also seen that the superfusion of ventricular strips with taurine-free medium produces a decrease in taurine content at the end of 120 min superfusion. Taurine levels can be restored by superfusion with 10 mM taurine; a linear relationship exists between external taurine and internal taurine levels.
Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips / Franconi F; Martini F; Stendardi I; Matucci R; Zilletti L; Giotti A. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - STAMPA. - 31:(1982), pp. 3181-3185.
Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips.
FRANCONI, FLAVIA;STENDARDI, ISABELLA;MATUCCI, ROSANNA;ZILLETTI, LUCILLA;GIOTTI, ALBERTO
1982
Abstract
Taurine increases the calcium levels in guinea-pig ventricular strips at external calcium concentrations of 0.45, 0.9 and 1.8 mM. At 2.7 mM calcium, however, a decrease is observed. Analogous changes occur in contractile force. It is also seen that the superfusion of ventricular strips with taurine-free medium produces a decrease in taurine content at the end of 120 min superfusion. Taurine levels can be restored by superfusion with 10 mM taurine; a linear relationship exists between external taurine and internal taurine levels.
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