Biomarkers are decision-making tools at the basis of clinical diagnostics and essential for guiding therapeutic treatments. In this context, autoimmune diseases represent a class of disorders that need early diagnosis and steady monitoring. In these diseases, the immune system recognizes some antigens no more as self and it is now accepted that post-translational modifications may affect the immunogenicity of self-protein antigens, triggering an autoimmune response. Therefore, posttranslationally modified peptides are the best candidate to develop synthetic probes detecting autoantibodies as disease biomarkers. A “Chemical Reverse Approach” to select synthetic peptides bearing specific post-translational modifications able to fishing out autoantibodies from patients’ biological fluids, can be successfully applied for the development of specific noninvasive diagnostic/prognostic assays of autoimmune diseases.
Peptides as autoimmune diseases antigenic probes - A peptide-based reverse approach to detect biomarkers of autoimmune diseases / M. C. Alcaro; F. Lolli; P. Migliorini; M. Chelli; P. Rovero; A. M. Papini. - In: CHIMICA OGGI-CHEMISTRY TODAY. - ISSN 0392-839X. - STAMPA. - 25:(2007), pp. 14-16.
Peptides as autoimmune diseases antigenic probes - A peptide-based reverse approach to detect biomarkers of autoimmune diseases
M. C. Alcaro;LOLLI, FRANCESCO;ROVERO, PAOLO;PAPINI, ANNA MARIA
2007
Abstract
Biomarkers are decision-making tools at the basis of clinical diagnostics and essential for guiding therapeutic treatments. In this context, autoimmune diseases represent a class of disorders that need early diagnosis and steady monitoring. In these diseases, the immune system recognizes some antigens no more as self and it is now accepted that post-translational modifications may affect the immunogenicity of self-protein antigens, triggering an autoimmune response. Therefore, posttranslationally modified peptides are the best candidate to develop synthetic probes detecting autoantibodies as disease biomarkers. A “Chemical Reverse Approach” to select synthetic peptides bearing specific post-translational modifications able to fishing out autoantibodies from patients’ biological fluids, can be successfully applied for the development of specific noninvasive diagnostic/prognostic assays of autoimmune diseases.File | Dimensione | Formato | |
---|---|---|---|
ChemistryToday_2007_25(3-suppl)_14-16(AntigenicProbes).pdf
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
160.01 kB
Formato
Adobe PDF
|
160.01 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.