A common polymorphism (rs2373115) in the GRB-associated binding protein 2 (GAB2) gene has been recently associated with the risk of developing Alzheimer's disease (AD) in 644 apolipoprotein E (ApoE) epsilon4 carriers. In order to assess the involvement of the GAB2 polymorphism in the risk of developing AD, we analyzed the genotype and allele distributions of the GAB2 rs2373115 polymorphism in 579 Italian subjects. Our results support a possible implication of GAB2 genetic variant in AD. However, the observed association was confined to ApoE epsilon4 non-carriers, thus suggesting a possible role of GAB2 as an independent risk factor for AD.

Implication of GAB2 Gene Polymorphism in Italian Patients with Alzheimer's Disease / Nacmias B; Tedde A; Bagnoli S; Cellini E; Guarnieri BM; Piacentini S; Sorbi S. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - STAMPA. - 16:(2009), pp. 513-515.

Implication of GAB2 Gene Polymorphism in Italian Patients with Alzheimer's Disease

NACMIAS, BENEDETTA;TEDDE, ANDREA;BAGNOLI, SILVIA;CELLINI, ELENA;PIACENTINI, SILVIA;SORBI, SANDRO
2009

Abstract

A common polymorphism (rs2373115) in the GRB-associated binding protein 2 (GAB2) gene has been recently associated with the risk of developing Alzheimer's disease (AD) in 644 apolipoprotein E (ApoE) epsilon4 carriers. In order to assess the involvement of the GAB2 polymorphism in the risk of developing AD, we analyzed the genotype and allele distributions of the GAB2 rs2373115 polymorphism in 579 Italian subjects. Our results support a possible implication of GAB2 genetic variant in AD. However, the observed association was confined to ApoE epsilon4 non-carriers, thus suggesting a possible role of GAB2 as an independent risk factor for AD.
2009
16
513
515
Nacmias B; Tedde A; Bagnoli S; Cellini E; Guarnieri BM; Piacentini S; Sorbi S
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/357618
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