We describe here the main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy. Two major applications of these compounds are described: as cancer therapeutics and as chemopreventive compounds. Both natural compounds, extracted fromplants or animals or produced by microbes (antibiotics), and syntheticcompounds, derived from natural prototype structures, are being used.We also focus on the molecular aspects of interactions with their recognized cellular targets, from DNA to microtubules. Some critical aspects of current cancer chemotherapy are also discussed, focusing on genetics and genomics, and the recent revolutionary theory of cancer: aneuploidy as the primum movens of cancer.

Natural compounds for cancer treatment and prevention / Nobili S; Lippi D; Witort E; Donnini M; Bausi L; Mini E; Capaccioli S.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 59:(2009), pp. 365-378.

Natural compounds for cancer treatment and prevention

NOBILI, STEFANIA;LIPPI, DONATELLA;WITORT, EWA JANINA
;
DONNINI, MARTINO;MINI, ENRICO
;
CAPACCIOLI, SERGIO
2009

Abstract

We describe here the main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy. Two major applications of these compounds are described: as cancer therapeutics and as chemopreventive compounds. Both natural compounds, extracted fromplants or animals or produced by microbes (antibiotics), and syntheticcompounds, derived from natural prototype structures, are being used.We also focus on the molecular aspects of interactions with their recognized cellular targets, from DNA to microtubules. Some critical aspects of current cancer chemotherapy are also discussed, focusing on genetics and genomics, and the recent revolutionary theory of cancer: aneuploidy as the primum movens of cancer.
59
365
378
Nobili S; Lippi D; Witort E; Donnini M; Bausi L; Mini E; Capaccioli S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/369971
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