Protease-activated receptors (PARs) are members of the G protein-coupled receptor superfamily that are activated by the proteolytic cleavage of their amino terminal domain. PARs are expressed in several tissues by a variety of cells and are implicated in numerous biologic effects, including coagulation, inflammation, mitogenesis and cell proliferation. PAR-2 is expressed by keratinocytes in the epidermis, being activated by trypsin-like enzymes such as mast-cell tryptase, and it affects epidermal pigmentation via modulation of melanosome uptake in vivo. Because vitiligo is a skin disorder characterized by melanocyte impairment and loss of melanin in keratinocytes, PAR-2 may be involved in this condition. Twenty-three vitiligo patients with active disease were studied. PAR-2 expression was significantly lower in lesional versus perilesional and normal epidermis, by both immunohistochemistry and molecular biology. Cultured keratinocytes from depigmented lesions exhibited a lower PAR-2 function compared to normal keratinocytes. PAR-2 expression appears reduced in vitiligo and its down-regulation seems associated with pigment loss. These data confirm the involvement of keratinocyte function in vitiligo process.

Protease-activated receptor-2 downregulation is associated to vitiligo lesions / Moretti S, Nassini R, Prignano F, Pacini A, Materazzi S, Naldini A, Simoni A, Baroni G, Pellerito S, Filippi I, Lotti T, Geppetti P, Massi D.. - In: PIGMENT CELL & MELANOMA RESEARCH. - ISSN 1755-1471. - ELETTRONICO. - 22:(2009), pp. 335-338. [10.1111/j.1755-148X.2009.00562.x]

Protease-activated receptor-2 downregulation is associated to vitiligo lesions

Moretti S;Nassini R;Prignano F;Pacini A;Materazzi S;Baroni G;Pellerito S;FILIPPI, ILARIA;Lotti T;Geppetti P;Massi D.
2009

Abstract

Protease-activated receptors (PARs) are members of the G protein-coupled receptor superfamily that are activated by the proteolytic cleavage of their amino terminal domain. PARs are expressed in several tissues by a variety of cells and are implicated in numerous biologic effects, including coagulation, inflammation, mitogenesis and cell proliferation. PAR-2 is expressed by keratinocytes in the epidermis, being activated by trypsin-like enzymes such as mast-cell tryptase, and it affects epidermal pigmentation via modulation of melanosome uptake in vivo. Because vitiligo is a skin disorder characterized by melanocyte impairment and loss of melanin in keratinocytes, PAR-2 may be involved in this condition. Twenty-three vitiligo patients with active disease were studied. PAR-2 expression was significantly lower in lesional versus perilesional and normal epidermis, by both immunohistochemistry and molecular biology. Cultured keratinocytes from depigmented lesions exhibited a lower PAR-2 function compared to normal keratinocytes. PAR-2 expression appears reduced in vitiligo and its down-regulation seems associated with pigment loss. These data confirm the involvement of keratinocyte function in vitiligo process.
2009
22
335
338
Moretti S, Nassini R, Prignano F, Pacini A, Materazzi S, Naldini A, Simoni A, Baroni G, Pellerito S, Filippi I, Lotti T, Geppetti P, Massi D.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/370465
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