The synthesis of N-protected glycosyl amino acids from amines has been investigated and it was found that, under microwave conditions, glycosylamines could be hydrolyzed leading to new products containing a glycosyl ester linkage. The efficiency of the microwave-induced glycosylation of aspartic acid was studied comparing the microwave activity between amide and ester bond formation. Different sugar moieties have been employed to demonstrate the simple and reproducible coupling methodology. New glycosyl ester compounds were further characterized by NMR spectroscopy.

Microwave-assisted reaction of glycosylamine with aspartic acid / F. Real-Fernández; F. Nuti; M.A. Bonache; M. Boccalini; S. Chimichi; M. Chelli; A.M. Papini. - In: AMINO ACIDS. - ISSN 0939-4451. - STAMPA. - 39:(2010), pp. 599-604. [10.1007/s00726-010-0484-8]

Microwave-assisted reaction of glycosylamine with aspartic acid

NUTI, FRANCESCA;CHIMICHI, STEFANO;PAPINI, ANNA MARIA
2010

Abstract

The synthesis of N-protected glycosyl amino acids from amines has been investigated and it was found that, under microwave conditions, glycosylamines could be hydrolyzed leading to new products containing a glycosyl ester linkage. The efficiency of the microwave-induced glycosylation of aspartic acid was studied comparing the microwave activity between amide and ester bond formation. Different sugar moieties have been employed to demonstrate the simple and reproducible coupling methodology. New glycosyl ester compounds were further characterized by NMR spectroscopy.
2010
39
599
604
F. Real-Fernández; F. Nuti; M.A. Bonache; M. Boccalini; S. Chimichi; M. Chelli; A.M. Papini
File in questo prodotto:
File Dimensione Formato  
AminoAcids_2010_39_599-604.pdf

Accesso chiuso

Tipologia: Altro
Licenza: Tutti i diritti riservati
Dimensione 257.57 kB
Formato Adobe PDF
257.57 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/373303
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 2
social impact