Lymphadenectomy and extended lymphadenectomy are still controversial issues in surgical oncology.The detection methods for metastatic lymph nodes include lymphoscintigraphy and radiolabelled antibody, but immunohistochemical sentinel lymph node (SLN) identification is commonly used. The potential diagnostic use of cell and tissue autofluorescence (AF) is well known. Here we review our studies on the application of AF-based techniques for diagnosiing metastatic lympg nodes. We had previously demonstrated that AF imaging allows discrimination between hyperplastic and primary neoplastic lymph nodes. Our more recent studies show that the combination of autofluorescence micrscopy can be applied to the diagnosis of secondary neoplastic lymph nodes in gastric and colorectal cancer. These techniques have been validated by histochemical and immunohistochemical methods. Studies are in progress to select the best due tracer for SLN identification, to improve image quality and to develop a software for automatic analysis of tissue AF to help the decision-making process during surgery

Colonic and gastric cancer metastatic lymph nodes: applications of autofluorescence-based techniques / D.Pantalone; M.Monici; G. Romano; F. Cialdai; R. Santi; F. Fusi; C. Comin; P. Bechi. - In: ONCOLOGY REVIEWS. - ISSN 1970-5565. - ELETTRONICO. - 4:(2010), pp. 15-23. [10.1007/s12156-009-0032-5]

Colonic and gastric cancer metastatic lymph nodes: applications of autofluorescence-based techniques

PANTALONE, DESIRE'
Writing – Original Draft Preparation
;
MONICI, MONICA
Supervision
;
ROMANO, GIOVANNI
Formal Analysis
;
CIALDAI, FRANCESCA
Investigation
;
R. Santi
Investigation
;
FUSI, FRANCO
Methodology
;
COMIN, CAMILLA EVA
Investigation
;
BECHI, PAOLO
Membro del Collaboration Group
2010

Abstract

Lymphadenectomy and extended lymphadenectomy are still controversial issues in surgical oncology.The detection methods for metastatic lymph nodes include lymphoscintigraphy and radiolabelled antibody, but immunohistochemical sentinel lymph node (SLN) identification is commonly used. The potential diagnostic use of cell and tissue autofluorescence (AF) is well known. Here we review our studies on the application of AF-based techniques for diagnosiing metastatic lympg nodes. We had previously demonstrated that AF imaging allows discrimination between hyperplastic and primary neoplastic lymph nodes. Our more recent studies show that the combination of autofluorescence micrscopy can be applied to the diagnosis of secondary neoplastic lymph nodes in gastric and colorectal cancer. These techniques have been validated by histochemical and immunohistochemical methods. Studies are in progress to select the best due tracer for SLN identification, to improve image quality and to develop a software for automatic analysis of tissue AF to help the decision-making process during surgery
2010
4
15
23
D.Pantalone; M.Monici; G. Romano; F. Cialdai; R. Santi; F. Fusi; C. Comin; P. Bechi
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Descrizione: Studio di autofluorescenza sui linfonodi metastatici di cancro del colon e dello stomaco
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/385672
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