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EnglishSneezing, cough, mucus secretion, and bronchoconstriction represent the main components of a coordinated and efficient reaction direct to expel or neutralize irritant agents from the respiratory system. A dense network of sensory nerves localized from the nose to the lower airways beneath the epithelium subserves this function. A variety of receptors and channels present in sensory nerve terminals by sensing irritant stimuli activate the system in emergence and initiate protective reflex responses, including cough. Previous and recent literature highlights the prominent role of some transient receptor potential (TRP) ion channels, and specifically the vanilloid 1 (TRPV1) and the ankyrin 1 (TRPA1) as sensors of airway irritation and initiators of the cough reflex.
Cough: The Emerging Role of the TRPA1 Channel / Geppetti P; Patacchini R; Nassini R; Materazzi S.. - In: LUNG. - ISSN 0341-2040. - ELETTRONICO. - 188 Suppl 1(2010), pp. S63-8.
| Titolo: | Cough: The Emerging Role of the TRPA1 Channel. | |
| Autori di Ateneo: | ||
| Autori: | GEPPETTI, PIERANGELO; NASSINI, ROMINA; Patacchini R; MATERAZZI, SERENA; Nassini R; Materazzi S. | |
| Anno di registrazione: | 2010 | |
| Rivista: | ||
| Volume: | 188 Suppl 1 | |
| Pagina iniziale: | S63 | |
| Pagina finale: | 8 | |
| Abstract: | Sneezing, cough, mucus secretion, and bronchoconstriction represent the main components of a coordinated and efficient reaction direct to expel or neutralize irritant agents from the respiratory system. A dense network of sensory nerves localized from the nose to the lower airways beneath the epithelium subserves this function. A variety of receptors and channels present in sensory nerve terminals by sensing irritant stimuli activate the system in emergence and initiate protective reflex responses, including cough. Previous and recent literature highlights the prominent role of some transient receptor potential (TRP) ion channels, and specifically the vanilloid 1 (TRPV1) and the ankyrin 1 (TRPA1) as sensors of airway irritation and initiators of the cough reflex. | |
| Handle: | http://hdl.handle.net/2158/394875 | |
| Appare nelle tipologie: | 1a - Articolo su rivista |
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|---|---|---|---|---|
| 2010_Lung_Geppetti et al_CoughTRPA1channel-Rev.pdf | Versione finale referata (Postprint, Accepted manuscript) | DRM non definito | Administrator Richiedi una copia |
http://hdl.handle.net/2158/394875
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