A method allowing the selective oxygen labelling of aliphatic polyacids, for example, succinic and glutaric acids, is reported. This process is based on the hydrolysis of a 3-alkyl-4-nitroisoxazol-5-yl group by Na18OH and affords the products in high yields. The same procedure was applied for the preparation of labelled aliphatic carboxylic acids.

Preparation of mono-labelled aliphatic polyacids via isoxazole derivatives / M. F. A. Adamo; P. Sarti-Fantoni; S. Chimichi; A. Sandrelli. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 51:(2010), pp. 6310-6312. [10.1016/j.tetlet.2010.09.113]

Preparation of mono-labelled aliphatic polyacids via isoxazole derivatives

CHIMICHI, STEFANO;
2010

Abstract

A method allowing the selective oxygen labelling of aliphatic polyacids, for example, succinic and glutaric acids, is reported. This process is based on the hydrolysis of a 3-alkyl-4-nitroisoxazol-5-yl group by Na18OH and affords the products in high yields. The same procedure was applied for the preparation of labelled aliphatic carboxylic acids.
2010
51
6310
6312
M. F. A. Adamo; P. Sarti-Fantoni; S. Chimichi; A. Sandrelli
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/397384
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