The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that are more reactive than O2 itself, which include hydrogen peroxide and superoxide. Although these are quite stable, they may be converted in the presence of transition metal ions, such as Fe(II), to the highly reactive oxygen species (hROS). hROS may exist as free hydroxyl radicals (HO), as bound (‘‘crypto’’) radicals or as Fe(IV)-oxo (ferryl) species and the somewhat less reactive, non-radical species, singlet oxygen. This review outlines the processes by which hROS may be formed, their damaging potential, and the evidence that they might have signaling functions. Since our understanding of the formation and actions of hROS depends on reliable procedures for their detection, particular attention is given to procedures for hROS detection and quantitation and their applicability to in vivo studies.

Highly reactive oxygen species: detection, formation and possible functions / W. Freinbichler; M.A. Colivicchi; C. Stefanini; L. Bianchi; C. Ballini; B. Misini; P. Weinberger; W. Linert; D. Vareslija; K.F. Tipton; L. Della Corte. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-9071. - STAMPA. - 68:(2011), pp. 2067-2079. [10.1007/s00018-011-0682-x]

Highly reactive oxygen species: detection, formation and possible functions

STEFANINI, CHIARA;BIANCHI, LORIA;BALLINI, CHIARA;DELLA CORTE, LAURA
2011

Abstract

The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that are more reactive than O2 itself, which include hydrogen peroxide and superoxide. Although these are quite stable, they may be converted in the presence of transition metal ions, such as Fe(II), to the highly reactive oxygen species (hROS). hROS may exist as free hydroxyl radicals (HO), as bound (‘‘crypto’’) radicals or as Fe(IV)-oxo (ferryl) species and the somewhat less reactive, non-radical species, singlet oxygen. This review outlines the processes by which hROS may be formed, their damaging potential, and the evidence that they might have signaling functions. Since our understanding of the formation and actions of hROS depends on reliable procedures for their detection, particular attention is given to procedures for hROS detection and quantitation and their applicability to in vivo studies.
2011
68
2067
2079
W. Freinbichler; M.A. Colivicchi; C. Stefanini; L. Bianchi; C. Ballini; B. Misini; P. Weinberger; W. Linert; D. Vareslija; K.F. Tipton; L. Della Corte...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/434670
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