An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.1) inhibitor coated gold nanoparticles is reported. This nanomaterial selectively inhibited the tumor-associated isoform CA IX overexpressed in hypoxic cancers over the ubiquitous, cytosolic housekeeping isozymes CA I and II and was membrane impermeant. As CA IX has an extracellular active site, the new nanomaterial which is confined to the extracellular space may be useful for imaging and treatment of hypoxic tumors.

Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II / M. Stiti;A. Cecchi;M. Rami;M. Abdaoui;V. Barragan-Montero;A. Scozzafava;Y. Guari;J. Winum;C. T. Supuran. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - STAMPA. - 130:(2008), pp. 16130-16131. [10.1021/ja805558k]

Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.

SCOZZAFAVA, ANDREA;SUPURAN, CLAUDIU TRANDAFIR
2008

Abstract

An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.1) inhibitor coated gold nanoparticles is reported. This nanomaterial selectively inhibited the tumor-associated isoform CA IX overexpressed in hypoxic cancers over the ubiquitous, cytosolic housekeeping isozymes CA I and II and was membrane impermeant. As CA IX has an extracellular active site, the new nanomaterial which is confined to the extracellular space may be useful for imaging and treatment of hypoxic tumors.
2008
130
16130
16131
M. Stiti;A. Cecchi;M. Rami;M. Abdaoui;V. Barragan-Montero;A. Scozzafava;Y. Guari;J. Winum;C. T. Supuran
File in questo prodotto:
File Dimensione Formato  
jacsnanoparticles.pdf

accesso aperto

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Open Access
Dimensione 131.31 kB
Formato Adobe PDF
131.31 kB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/594269
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 98
  • ???jsp.display-item.citation.isi??? 91
social impact