A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs / L. Guandalini; E. Martini; L. Di Cesare Mannelli; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M.N. Romanelli. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 22:(2012), pp. 1936-1939. [10.1016/j.bmcl.2012.01.045]
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs
GUANDALINI, LUCA;MARTINI, ELISABETTA;DI CESARE MANNELLI, LORENZO;DEI, SILVIA;MANETTI, DINA;SCAPECCHI, SERENA;TEODORI, ELISABETTA;GHELARDINI, CARLA;ROMANELLI, MARIA NOVELLA
2012
Abstract
A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
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