Development of low methoxy amidated pectin-based mucoadhesive patches for buccal delivery of triclosan: Effect of cyclodextrin complexation

A novel mucoadhesive buccal patch formulation of triclosan (TR), a broad spectrum antibacterial agent, was developed using low methoxy amidated pectin (AMP). The integrity of AMP matrix was improved by addition of 20% (w/w) Carbopol (CAR). The efficiency of ß-cyclodextrin-epichlorohydrin polymer (EPIßCD) and anionic carboxymethylated ß-cyclodextrin-epichlorohydrin polymer (CMEPIßCD) in optimizationof TR solubility and release from such a matrix was investigated and confronted to that of parent ß-cyclodextrin (ßCD). Loading of TR/ßCD co-ground complex into AMP/CAR matrix resulted in a biphasic release profile which was sensitive upon the hydration degree of the matrix, due to lower solubilizing efficiency of ßCD, while the drug release from patches loaded with TR/EPIßCD complex was significantly faster with a constant release rate. Microbiological studies evidenced faster onset and more pronounced antibacterial action of TR/EPIßCD loaded patches, clearly demonstrating their good therapeutic potential in eradication of Streptococcus mutans, a cariogenic bacteria, from the oral cavity.