A series of 7‐methylpyrazolo[1,5‐a]pyrimidines were reacted with dimethylformamide dimethylacetal to give the corresponding dimethylaminovinyl derivatives. These were reacted with ammonium acetate affording, through a ring closure, a number of 6‐methylpyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidines bearing various substituents on the pyrazole ring. The 6‐acetyl‐2‐hydroxy‐7‐methylpyrazolo[1,5‐a]pyrimidine was used as starting material for obtaining some O‐alkyl derivatives. Catalytic transfer hydrogenation of 2‐benzyloxy‐6‐methylpyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidine led to the 2‐hydroxy derivative
REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL) PYRAZOLO[1,5-A]PYRIMIDINES: SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS.1 / F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; M. CASILLI. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - STAMPA. - 31:(1994), pp. 1193-1198. [10.1002/jhet.5570310516]
REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL) PYRAZOLO[1,5-A]PYRIMIDINES: SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS.1
BRUNI, FABRIZIO;SELLERI, SILVIA;COSTANZO, ANNARELLA;GUERRINI, GABRIELLA;
1994
Abstract
A series of 7‐methylpyrazolo[1,5‐a]pyrimidines were reacted with dimethylformamide dimethylacetal to give the corresponding dimethylaminovinyl derivatives. These were reacted with ammonium acetate affording, through a ring closure, a number of 6‐methylpyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidines bearing various substituents on the pyrazole ring. The 6‐acetyl‐2‐hydroxy‐7‐methylpyrazolo[1,5‐a]pyrimidine was used as starting material for obtaining some O‐alkyl derivatives. Catalytic transfer hydrogenation of 2‐benzyloxy‐6‐methylpyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidine led to the 2‐hydroxy derivative
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