We have previously demonstrated in vitro that ubiquitous free radical scavenger coenzyme Q10 prevents keratocyte apoptosis induced by excimer laser irradiation more efficiently than other antioxidants. We showed that its anti apoptotic property is independent of its free radical scavenging ability and is related to direct inhibition of PTP (permeability transition pore) opening and mitochondrial depolarization. Here, we demonstrate in vivo, that CoQ10 can efficiently protect rat's corneas and rabbit's retinas irradiated with UVC. Therefore, we propose application of CoQ10 as countermeasure to prevent micro radiation-induced eye damage during interplanetary space exploration.

Topical administration of the mithocondrial PTP opening inhibitor CoQ10 prevents apoptotic cell death induced by UVC-irradiation in rat's corneas and rabbit's retinas / Papucci L; Witort E; Schiavone N; Donnini M; Lapucci A; Lulli M; Lazzarano S; Simoncini M; Mazzoni T; Falciani P; Capaccioli S. - In: JOURNAL OF GRAVITATIONAL PHYSIOLOGY. - ISSN 1077-9248. - STAMPA. - 15:(2008), pp. 311-312. (Intervento presentato al convegno Life in Space for Life on Earth tenutosi a Angers, France nel 22 June 2008through27 July 2008).

Topical administration of the mithocondrial PTP opening inhibitor CoQ10 prevents apoptotic cell death induced by UVC-irradiation in rat's corneas and rabbit's retinas.

PAPUCCI, LAURA;WITORT, EWA JANINA;SCHIAVONE, NICOLA;DONNINI, MARTINO;LAPUCCI, ANDREA;LULLI, MATTEO;CAPACCIOLI, SERGIO
2008

Abstract

We have previously demonstrated in vitro that ubiquitous free radical scavenger coenzyme Q10 prevents keratocyte apoptosis induced by excimer laser irradiation more efficiently than other antioxidants. We showed that its anti apoptotic property is independent of its free radical scavenging ability and is related to direct inhibition of PTP (permeability transition pore) opening and mitochondrial depolarization. Here, we demonstrate in vivo, that CoQ10 can efficiently protect rat's corneas and rabbit's retinas irradiated with UVC. Therefore, we propose application of CoQ10 as countermeasure to prevent micro radiation-induced eye damage during interplanetary space exploration.
2008
Life in Space for Life on Earth
Life in Space for Life on Earth
Angers, France
22 June 2008through27 July 2008
Papucci L; Witort E; Schiavone N; Donnini M; Lapucci A; Lulli M; Lazzarano S; Simoncini M; Mazzoni T; Falciani P; Capaccioli S
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/748725
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact