Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM.
Synthesis and urease enzyme inhibitory effects of some dicoumarols / K. M. Khan;S. Iqbal;M. A. Lodhi;G. M. Maharvi;S. Perveen;M. I. Choudhary;A. Ur-Rahman;Z. H. Chohan;C. T. Supuran. - In: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. - ISSN 1475-6366. - STAMPA. - 19:(2004), pp. 367-371.
Synthesis and urease enzyme inhibitory effects of some dicoumarols.
SUPURAN, CLAUDIU TRANDAFIR
2004
Abstract
Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM.
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