OXALIPLATIN ELICITS MECHANICAL AND COLD ALLODYNIA IN RODENTS VIA TRPA1 RECEPTOR STIMULATION

Platinum-based anticancer drugs cause neurotoxicity. We hypothesized that the transient receptor potential ankyrin 1 (TRPA1), a cation channel activated by oxidative stress and cold temperature, contributes to mechanical and cold hypersensitivity caused by oxaliplatin and cisplatin. Oxaliplatin administration caused mechanical and coldallodynia in mice. Both responses were absent in TRPA1-deficient mice. TRPA1 is therefore required for oxaliplatin-evoked mechanical and cold hypersensitivity, and contributes to cisplatin-evoked mechanicalallodynia