The Burkholderia cepacia complex (Bcc) is a group of 18 closely related bacterial species. They are important opportunistic pathogens that infect the airways of Cystic Fibrosis patients characterized by high resistance level to many classes of antibiotics. Essential oils, secondary plant metabolites, possess antibacterial, antifungal and/or antiviral properties and have been screened worlwide as potential sources of new antimicrobial compounds as alternatives to synthetic antibiotics. The bacterial effect of essential oils is mainly due to compounds derived from terpenes and terpenoids that seem to act on the bacterial membrane affecting the permeability, the transport of nutrients and the membrane potential of the cells. In our study we screened by disk-diffusone method, the antimicrobial activity of 6 different essential oils: clove (Eugenia caryophyllata), lavender (Lavandula hybrida), oregano (Origanum vulgare), rosemary (Rosmarinus officinalis), tea tree oil (Melaleuca alternifolia) and thyme (Thymus vulgaris) against 85 Burkholderia strains, representative of all the 18 Bcc species. Our data demonstrated that oregano, thyme and clove essentail oils exhibited considerable inhibitory effects against all the organisms under test even against ciprofloxacin resistant strains. The Minimal Inhibitory Concentration (MIC) determination for oregano, thyme and clove essential oils against a subset of strains is in progress.
Novel natural antibiotics: inhibiton of Burkholderia cepacia complex cell growth by essential oils from medicinal plants / R. Fani; E. Perrin; I. Maida; M. Fondi; C. Chiellini; A. Mengoni; A. Bilia; S. Biffi; V. Maggini; L. Gori; A. Vannacci; M. Barnabei; G. Pesavento; C. Calonico; S. Mocali; A. Fabiani; F. Firenzuoli; A. Lo Nostro. - STAMPA. - (2013), pp. 45-45. (Intervento presentato al convegno Microbiology 2013 tenutosi a Ischia, Italy nel 19-21 settembre).
Novel natural antibiotics: inhibiton of Burkholderia cepacia complex cell growth by essential oils from medicinal plants
FANI, RENATO;PERRIN, ELENA;MAIDA, ISABEL;FONDI, MARCO;MENGONI, ALESSIO;BILIA, ANNA RITA;VANNACCI, ALFREDO;PESAVENTO, GIOVANNA;LO NOSTRO, ANTONELLA
2013
Abstract
The Burkholderia cepacia complex (Bcc) is a group of 18 closely related bacterial species. They are important opportunistic pathogens that infect the airways of Cystic Fibrosis patients characterized by high resistance level to many classes of antibiotics. Essential oils, secondary plant metabolites, possess antibacterial, antifungal and/or antiviral properties and have been screened worlwide as potential sources of new antimicrobial compounds as alternatives to synthetic antibiotics. The bacterial effect of essential oils is mainly due to compounds derived from terpenes and terpenoids that seem to act on the bacterial membrane affecting the permeability, the transport of nutrients and the membrane potential of the cells. In our study we screened by disk-diffusone method, the antimicrobial activity of 6 different essential oils: clove (Eugenia caryophyllata), lavender (Lavandula hybrida), oregano (Origanum vulgare), rosemary (Rosmarinus officinalis), tea tree oil (Melaleuca alternifolia) and thyme (Thymus vulgaris) against 85 Burkholderia strains, representative of all the 18 Bcc species. Our data demonstrated that oregano, thyme and clove essentail oils exhibited considerable inhibitory effects against all the organisms under test even against ciprofloxacin resistant strains. The Minimal Inhibitory Concentration (MIC) determination for oregano, thyme and clove essential oils against a subset of strains is in progress.
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