Suicidal ideation in a European Huntington's disease population

Hubers, Anna A. M.; Erik van Duijn,; Roos, Raymund A. C.; Craufurd, David; Rickards, Hugh; Bernhard Landwehrmeyer, G.; van der Mast, Rose C.; Giltay, Erik J.; Bachoud Lévi AC,; Bentivoglio, Ar; Biunno, I; Bonelli, Rm; Burgunder, Jm; Dunnett, Sb; Ferreira, Jj; Handley, Oj; Heiberg, A; Llmann, Ti; Landwehrmeyer, Gb; Levey, J; Ramos Arroyo MA,; Nielsen, Je; Prokoivisto, S; Päivärinta, M; Roos, Ra; Rojo Sebastián, A; Tabrizi, Sj; Vandenberghe, W; Verellen Dumoulin, C; Zaremba, J; Uhrova, T; Wahlström, J; Barth, K; Correia Guedes, L; Finisterra, Am; Garde, Mb; Bos, R; Betz, S; Callaghan, J; Fullam, R; Ecker, D; Nielsen, Mg; Handley, Oj; Hvalstedt, C; Held, C; Koppers, K; Laurà, M; Horta, Sm; Descals, Am; Mestre, T; Minster, S; Monza, D; Mütze, L; Oehmen, M; Townhill, J; Orth, M; Padieu, H; Paterski, L; Peppa, N; Pro Koivisto, S; Roedig, V; Rialland, A; Røren, N; Šašinková, P; Seliverstov, Y; Cubillo, Pt; Walsem, Mr; Wright, A; da Silva WV,; Witjes Ané MN,; Yudina, E; Zielonka, D; Zielonka, E; Zinzi, P; Bonelli, Rm; Herranhof, B; Holl, A; Kapfhammer, Hp; Koppitz, M; Magnet, M; Otti, D; Painold, A; Reisinger, K; Scheibl, M; Hecht, K; Lilek, S; Müller, N; Schöggl, H; Ullah, J; Brugger, F; Hepperger, C; Hotter, A; Seppi, K; Wenning, G; Buratti, L; Hametner, Em; Holas, C; Hametner, Em; Hussl, A; Poewe, W; Braunwarth, Em; Sprenger, F; Müller, C; Lilek, S; Sinadinosa, D; Walleczek, Am; Bonelli, Rm; Ladurner, G; Staffen, W; Flamez, A; Morez, V; de Raedt, S; Boogaerts, A; Vandenberghe, W; van Reijen, D; Klempíř, J; Majerová, V; Roth, J; Hartikainen, P; Hiivola, H; Martikainen, K; Tuuha, K; Ignatius, J; Kärppä, M; Åman, J; Mustonen, A; Kajula, O; Santala, M; Allain, P; Guérid, Ma; Gohier, B; Olivier, A; Prundean, A; Scherer Gagou, C; Verny, C; Bost, M; Babiloni, B; Debruxelles, S; Duché, C; Goizet, C; Lafoucrière, D; Jameau, L; Spampinato, U; De Bruycker, C; Cabaret, M; Carette, As; Defebvre, L; Decorte, E; Delval, A; Delliaux, M; Destee, A; Dujardin, K; Peter, M; Plomhouse, L; Sablonnière, B; Simonin, C; Defebvre, L; Lemaire, Mh; Manouvrier, S; Thibault Tanchou, S; Vuillaume, I; Krystkowiak, P; Duru, C; Roussel, M; Wannepain, S; Berrissoul, H; Bellonet, M; Courtin, F; Mantaux, B; Fasquel, V; Godefroy, O; Azulay, Jp; Fluchère, F; Delfini, M; Eusebio, A; Mundler, L; Longato, N; Rudolf, G; Steinmetz, G; Tranchant, C; Wagner, C; Zimmermann, M; Marcel, C; Calvas, F; Pariente, J; Démonet, Jf; Cheriet, S; Kosinski, Cm; Milkereit, E; Probst, D; Reetz, K; Sass, C; Schiefer, J; Schlangen, C; Werner, Cj; Gelderblom, H; Priller, J; Prüß, H; Spruth, Ej; Andrich, J; Ellrichmann, G; Hoffmann, R; Kaminski, B; Saft, C; Stamm, C; Lange, H; Bosredon, C; Maass, A; Schmidt, S; Storch, A; Wolz, M; Kohl, Z; Winkler, J; Capetian, P; Lambeck, J; Zucker, B; Boelmans, K; Ganos, C; Goerendt, I; Hidding, U; Lewerenz, J; Münchau, A; Orth, M; Schmalfeld, J; Stubbe, L; Zittel, S; Diercks, G; Dressler, D; Gorzolla, H; Schrader, C; Tacik, P; Heinicke, W; Longinus, B; Bürk, K; Möller, Jc; Rissling, I; Mühlau, M; Peinemann, A; Städtler, M; Weindl, A; Winkelmann, J; Ziegler, C; Bohlen, S; Hölzner, E; Lange, H; Reilmann, R; Sass, C; Dose, M; Leythaeuser, G; Marquard, R; Raab, T; Schrenk, C; Schuierer, M; Barth, K; Buck, A; Connemann, J; Ecker, D; Eschenbach, C; Held, C; Landwehrmeyer, B; Lezius, F; Nepper, S; Niess, A; Orth, M; Schwenk, D; Süßmuth, S; Trautmann, S; Weydt, P; Cormio, C; Sciruicchio, V; Serpino, C; Tommaso, M; Capellari, S; Cortelli, P; Gallassi, R; Poda, R; Rizzo, G; Scaglione, C; Bertini, E; Ghelli, Elena; Ginestroni, Andrea; Massaro, F; Mechi, Claudia; Paganini, Marco; Piacentini, Silvia; Pradella, Silvia; Romoli, Am; Sorbi, Sandro; Abbruzzese, G; di Poggio MB,; Di Maria, E; Ferrandes, G; Mandich, P; Marchese, R; Albanese, A; Di Bella, D; Di Donato, S; Gellera, C; Genitrini, S; Mariotti, C; Monza, D; Nanetti, L; Paridi, D; Soliveri, P; Tomasello, C; De Michele, G; Di Maio, L; Salvatore, E; Rinaldi, C; Rossi, F; Massarelli, M; Roca, A; Ammendola, S; Russo, Cv; Squitieri, F; Elifani, F; Maglione, V; Di Pardo, A; Alberti, S; Griguoli, A; Amico, E; Martino, T; Petrollini, M; Bentivoglio, Ar; Catalli, C; Di Giacopo, R; Fasano, A; Frontali, M; Guidubaldi, A; Ialongo, T; Jacopini, G; Loria, G; Piano, C; Chiara, P; Quaranta, D; Romano, S; Soleti, F; Spadaro, M; Zinzi, P; Rinaldi, C; Rossi, F; Massarelli, M; Roca, A; Ammendola, S; Russo, Cv; Squitieri, F; Elifani, F; Maglione, V; Alberti, S; Griguoli, A; Amico, E; Martino, T; Petrollini, M; Bentivoglio, Ar; Catalli, C; Di Giacopo, R; Fasano, A; Frontali, M; Guidubaldi, A; Ialongo, T; Jacopini, G; Loria, G; Piano, C; Chiara, P; Quaranta, D; Romano, S; Soleti, F; Spadaro, M; Zinzi, P; van Hout MS,; van Vugt JP,; Weert, A; Bolwijn, J; Dekker, M; Leenders, K; Kremer, Hp; Bos, R; Dumas, Em; van den Bogaard SJ,; Roos, Ra; 't Hart EP,; van Duijn, E; Økland, E; Hauge, E; Tyvoll, H; Heiberg, A; Walsem, Mr; Frich, J; Aaserud, O; Wehus, R; Bjørgo, K; Fannemel, M; Gørvell, P; Lorentzen, E; Koivisto, Sp; Retterstøl, L; Overland, T; Stokke, B; Sando, B; Dziadkiewicz, A; Nowak, M; Robowski, P; Sitek, E; Slawek, J; Soltan, W; Szinwelski, M; Blaszcyk, M; Boczarska Jedynak, M; Ciach Wysocka, E; Gorzkowska, A; Jasinska Myga, B; Opala, G; Kłodowska Duda, G; Stompel, D; Banaszkiewicz, K; Boćwińska, D; Szczudlik, A; Rudzińska, M; Wójcik, M; Dec, M; Krawczyk, M; Jaremek, Kb; Szczygieł, E; Stenwak, A; Ielewska, Aw; Bryl, A; Ciesielska, A; Klimberg, A; Marcinkowski, J; Sempołowicz, J; Zielonka, D; Samara, H; Wiśniewski, B; Janik, P; Gogol, A; Kwiecinski, H; Jamrozik, Z; Kaminska, A; Antczak, J; Jachinska, K; Rakowicz, M; Richter, P; Rola, R; Ryglewicz, D; Sienkiewicz Jarosz, H; Stępniak, I; Witkowski, G; Zdzienicka, E; Zaremba, J; Sułek, A; Krysa, W; Stępniak, I; Zieora Jakutowicz, K; Júlio, F; Januário, C; Mestre, T; Correia Guedes, L; Coelho, M; Mendes, T; Valadas, A; Ferreira, Jj; Timóteo, Â; Costa, C; Cavaco, S; Damásio, J; Loureiro, R; Magalhães, M; Andrade, C; Gago, M; Garrett, C; Guerra, Mr; Lima, J; Massano, J; Meireles, J; Herrera, Cd; Garcia, Pm; Barrero, F; Morales, B; Cubo, E; Mariscal, N; Sánchez, J; Alonso Frech, F; Perez, Mr; Fenollar, M; García, Rg; Quiroga, Pp; Rivera, Sv; Villanueva, C; Alegre, J; Bascuñana, M; Caldentey, Jg; Ventura, Mf; Ribas, Gg; Yébenes, Jg; López Sendón Moreno JL,; Cubillo, Pt; García Ruíz PJ,; Martínez Descals, A; Artiga, Mj; Sánchez, V; Guerrero, R; Bárcenas, Ah; Noguera Perea MF,; Fortuna, L; Martirio, M; Torres, A; Reinante, G; Moreau, Lv; Barbera, Ma; Guia, Db; Hernanz, Lc; Catena, Jl; Sebastián, Ar; Ferrer, Pq; Carruesco, Gt; Bas, J; Busquets, N; Calopa, M; Elorza, Md; Díez AjaLópez, C; Terol, Sd; Robert, Mf; Ruíz, Bg; Casado, Ag; Martínez, Ih; Viladrich, Cm; Càrdenas, Rp; Roca, E; Llesoy, Jr; Idiago, Jm; Vergara, Mr; García, Ss; Riballo, Av; González, Sg; Guisasola, Lm; Salvador, C; San Martín ES,; González, M; Gorospe, A; Legarda, I; Arques, Pn; Torres Rodríguez MJ,; Vives, B; Gaston, I; Ramos Arroyo MA,; Martinez Jaurrieta MD,; Manuel, J; Moreno, G; Peña, Jc; Avarvarei, Ld; Bastida, Am; Recio, Mf; Vergé, Lr; Sánchez, Vs; Carrillo, F; Cáceres, Mt; Mir, P; Suarez, Mj; Bosca, M; Burguera, Ja; Garcia, Ac; Brugada, Fc; Martínez, Lm; Val, Jl; Loutfi, G; Olofsson, C; Stattin, El; Westman, L; Wikström, B; Lhagen, Se; Paucar, M; Svenningsson, P; Reza Soltani TW,; Höglund, A; Sandström, B; Wahlström, J; Høsterey Ugander, U; Fredlund, G; Constantinescu, R; Neleborn Lingefjärd, L; Tedr off, J; Esmaeilzadeh, M; Winnberg, E; Pålhagen, S; Svennigsson, P; Paucar, M; Riza Soltani TW,; Sundblom, J; Johansson, A; Wiklund, L; Ekwall, C; Göller, Ml; Petersén, A; Reimer, J; Widner, H; Burgunder, Jm; Stebler, Y; Kaelin, A; Romero, I; Schüpbach, M; Weber, S; Miedzybrodzka, Z; Rae, D; Downie, L; Simpson, S; Summers, F; Ure, A; Jack, R; Matheson, K; Akhtar, S; Crooks, J; Curtis, A; Souza, J; Rickards, H; Wright, J; Hayward, B; Sieradzan, K; Wright, A; Barker, Ra; O'Keefe, D; Di Pietro, A; Fisher, K; Hill, S; Mason, S; Swain, R; Valle, N; Guzman,; Bisson, J; Busse, M; Butcher, C; Callaghan, J; Clenaghan, C; Dunnett, S; Fullam, R; Handley, O; Hunt, S; Hughes, A; Johnstone, C; Jones, L; Jones, U; Khalil, H; Minster, S; Owen, M; Price, K; Rose, Le; Townhill, J; Rosser, A; Porteous, M; Edwards, M; C, Ho; Mcgill, M; Pearson, P; Brockie, P; Foster, J; Johns, N; Mckenzie, S; Rothery, J; Thomas, G; Yates, S; Miller, J; Ritchie, S; Burrows, L; Fletcher, A; Harding, A; Laver, F; Silva, M; Thomson, A; Rowett, L; Gallantrae, D; Longthorpe, M; Markova, I; Raman, A; Hamer, S; Wild, S; Yarduiman, P; Chu, C; Kraus, A; Wild, S; Yardumian, P; Musgrave, H; Rowett, L; Toscano, J; Jamieson, S; Hobson, E; Clayton, C; Dipple, H; Middleton, J; Freire Patino, D; Andrews, T; Dougherty, A; Kavalier, F; Golding, C; Laing, H; Lashwood, A; Robertson, D; Ruddy, D; Whaite, A; Santhouse, A; Patton, M; Peterson, M; Rose, S; Andrews, T; Bruno, S; Chu, E; Doherty, K; Golding, C; Haider, S; Hensman, D; Lahiri, N; Lewis, M; Novak, M; Patel, A; Robertson, N; Rosser, E; Tabrizi, S; Taylor, R; Warner, T; Wild, E; Craufurd, D; Fullam, R; Howard, L; Sollom, A; Snowden, J; Thompson, J; Callaghan, J; Jones, M; Murphy, H; Trender Gerhard, I; Rogers, D; Bek, J; Oughton, E; Johnson, L; Hare, M; Arran, N; Verstraelen, N; Partington Jones, L; Huson, S; Stopford, C; Westmoreland, L; Davidson, J; Morgan, K; Savage, L; Singh, B; Komati, S; Nemeth, Ah; Armstrong, R; Valentine, R; Siuda, G; Harrison, D; Hughes, M; Parkinson, A; Soltysiak, B; Burn, J; Coleman, C; Bandmann, O; Bradbury, A; Gill, P; Fairtlough, H; Fillingham, K; Foustanos, I; Kazoka, M; O'Donovan, K; Peppa, N; Taylor, C; Tidswell, K; Quarrell, O.

doi:10.1016/j.jad.2013.06.001

BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD. METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis. RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive. LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated. CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.

Suicidal ideation in a European Huntington's disease population / Anna A.M. Hubers;Erik van Duijn;Raymund A.C. Roos;David Craufurd;Hugh Rickards;G. Bernhard Landwehrmeyer;Rose C. van der Mast;Erik J. Giltay; Bachoud-Lévi AC; Bentivoglio AR; Biunno I; Bonelli RM; Burgunder JM; Dunnett SB; Ferreira JJ; Handley OJ; Heiberg A; llmann TI; Landwehrmeyer GB; Levey J; Ramos-Arroyo MA; Nielsen JE; ProKoivisto S; Päivärinta M; Roos RA; Rojo Sebastián A; Tabrizi SJ; Vandenberghe W; Verellen- Dumoulin C; Zaremba J; Uhrova T; Wahlström J; Barth K; Correia-Guedes L; Finisterra AM; Garde MB; Bos R; Betz S; Callaghan J; Fullam R; Ecker D; Nielsen MG; Handley OJ; Hvalstedt C; Held C; Koppers K; Laurà M; Horta SM; Descals AM; Mestre T; Minster S; Monza D; Mütze L; Oehmen M; Townhill J; Orth M; Padieu H; Paterski L; Peppa N; Pro Koivisto S; Roedig V; Rialland A; Røren N; Šašinková P; Seliverstov Y; Cubillo PT; Walsem MR; Wright A; da Silva WV; Witjes-Ané MN; Yudina E; Zielonka D; Zielonka E; Zinzi P; Bonelli RM; Herranhof B; Holl A; Kapfhammer HP; Koppitz M; Magnet M; Otti D; Painold A; Reisinger K; Scheibl M; Hecht K; Lilek S; Müller N; Schöggl H; Ullah J; Brugger F; Hepperger C; Hotter A; Seppi K; Wenning G; Buratti L; Hametner EM; Holas C; Hametner EM; Hussl A; Poewe W; Braunwarth EM; Sprenger F; Müller C; Lilek S; Sinadinosa D; Walleczek AM; Bonelli RM; Ladurner G; Staffen W; Flamez A; Morez V; de Raedt S; Boogaerts A; Vandenberghe W; van Reijen D; Klempíř J; Majerová V; Roth J; Hartikainen P; Hiivola H; Martikainen K; Tuuha K; Ignatius J; Kärppä M; Åman J; Mustonen A; Kajula O; Santala M; Allain P; Guérid MA; Gohier B; Olivier A; Prundean A; Scherer- Gagou C; Verny C; Bost M; Babiloni B; Debruxelles S; Duché C; Goizet C; Lafoucrière D; Jameau L; Spampinato U; De Bruycker C; Cabaret M; Carette AS; Defebvre L; Decorte E; Delval A; Delliaux M; Destee A; Dujardin K; Peter M; Plomhouse L; Sablonnière B; Simonin C; Defebvre L; Lemaire MH; Manouvrier S; Thibault-Tanchou S; Vuillaume I; Krystkowiak P; Duru C; Roussel M; Wannepain S; Berrissoul H; Bellonet M; Courtin F; Mantaux B; Fasquel V; Godefroy O; Azulay JP; Fluchère F; Delfini M; Eusebio A; Mundler L; Longato N; Rudolf G; Steinmetz G; Tranchant C; Wagner C; Zimmermann M; Marcel C; Calvas F; Pariente J; Démonet JF; Cheriet S; Kosinski CM; Milkereit E; Probst D; Reetz K; Sass C; Schiefer J; Schlangen C; Werner CJ; Gelderblom H; Priller J; Prüß H; Spruth EJ; Andrich J; Ellrichmann G; Hoffmann R; Kaminski B; Saft C; Stamm C; Lange H; Bosredon C; Maass A; Schmidt S; Storch A; Wolz M; Kohl Z; Winkler J; Capetian P; Lambeck J; Zucker B; Boelmans K; Ganos C; Goerendt I; Hidding U; Lewerenz J; Münchau A; Orth M; Schmalfeld J; Stubbe L; Zittel S; Diercks G; Dressler D; Gorzolla H; Schrader C; Tacik P; Heinicke W; Longinus B; Bürk K; Möller JC; Rissling I; Mühlau M; Peinemann A; Städtler M; Weindl A; Winkelmann J; Ziegler C; Bohlen S; Hölzner E; Lange H; Reilmann R; Sass C; Dose M; Leythaeuser G; Marquard R; Raab T; Schrenk C; Schuierer M; Barth K; Buck A; Connemann J; Ecker D; Eschenbach C; Held C; Landwehrmeyer B; Lezius F; Nepper S; Niess A; Orth M; Schwenk D; Süßmuth S; Trautmann S; Weydt P; Cormio C; Sciruicchio V; Serpino C; Tommaso M; Capellari S; Cortelli P; Gallassi R; Poda R; Rizzo G; Scaglione C; Bertini E; Ghelli E; Ginestroni A; Massaro F; Mechi C; Paganini M; Piacentini S; Pradella S; Romoli AM; Sorbi S; Abbruzzese G; di Poggio MB; Di Maria E; Ferrandes G; Mandich P; Marchese R; Albanese A; Di Bella D; Di Donato S; Gellera C; Genitrini S; Mariotti C; Monza D; Nanetti L; Paridi D; Soliveri P; Tomasello C; De Michele G; Di Maio L; Salvatore E; Rinaldi C; Rossi F; Massarelli M; Roca A; Ammendola S; Russo CV; Squitieri F; Elifani F; Maglione V; Di Pardo A; Alberti S; Griguoli A; Amico E; Martino T; Petrollini M; Bentivoglio AR; Catalli C; Di Giacopo R; Fasano A; Frontali M; Guidubaldi A; Ialongo T; Jacopini G; Loria G; Piano C; Chiara P; Quaranta D; Romano S; Soleti F; Spadaro M; Zinzi P; Rinaldi C; Rossi F; Massarelli M; Roca A; Ammendola S; Russo CV; Squitieri F; Elifani F; Maglione V; Alberti S; Griguoli A; Amico E; Martino T; Petrollini M; Bentivoglio AR; Catalli C; Di Giacopo R; Fasano A; Frontali M; Guidubaldi A; Ialongo T; Jacopini G; Loria G; Piano C; Chiara P; Quaranta D; Romano S; Soleti F; Spadaro M; Zinzi P; van Hout MS; van Vugt JP; Weert A; Bolwijn J; Dekker M; Leenders K; Kremer HP; Bos R; Dumas EM; van den Bogaard SJ; Roos RA; 't Hart EP; van Duijn E; Økland E; Hauge E; Tyvoll H; Heiberg A; Walsem MR; Frich J; Aaserud O; Wehus R; Bjørgo K; Fannemel M; Gørvell P; Lorentzen E; Koivisto SP; Retterstøl L; Overland T; Stokke B; Sando B; Dziadkiewicz A; Nowak M; Robowski P; Sitek E; Slawek J; Soltan W; Szinwelski M; Blaszcyk M; Boczarska-Jedynak M; Ciach-Wysocka E; Gorzkowska A; Jasinska-Myga B; Opala G; Kłodowska-Duda G; Stompel D; Banaszkiewicz K; Boćwińska D; Szczudlik A; Rudzińska M; Wójcik M; Dec M; Krawczyk M; Jaremek KB; Szczygieł E; Stenwak A; ielewska AW; Bryl A; Ciesielska A; Klimberg A; Marcinkowski J; Sempołowicz J; Zielonka D; Samara H; Wiśniewski B; Janik P; Gogol A; Kwiecinski H; Jamrozik Z; Kaminska A; Antczak J; Jachinska K; Rakowicz M; Richter P; Rola R; Ryglewicz D; 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