Beneficial effects of oleuropein aglycone in Alzheimer's disease models and a study of autophagy in neurodegeneration and development of the brain

Mounting evidence supports the beneficial effects of the Mediterranean diet in preventing age-related dysfunctions, neurodegenerative diseases and in attenuating AD-like pathology and cognitive deterioration. We aimed to test the effect of Oleuropein Aglycone, the main polyphenol found in olive oil, on Aß aggregation using a rat model and a transgenic mouse model of Aß deposition. Following the modulatory effect of Oleuropein Aglycone on the autophagic flux, we investigated the role of autophagy in neurodevelopment through knockout autophagic genes in zebrafish.