A micellar formulation based on the use of an amphiphilic derivative of chitosan (quaternary-ammonium-palmitoyl-glycol-chitosan, GCPQ) has been succesfully developed to improve the celecoxib solubility and therapeutic effectiveness.
Development of a chitosan-derivative micellar formulation to improve celecoxib asolubility and bioavailability / Natascia Mennini; Sandra Furlanetto; Marco Bragagni; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Paola Mura. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - STAMPA. - 40:(2014), pp. 1494-1502. [10.3109/03639045.2013.831440]
Development of a chitosan-derivative micellar formulation to improve celecoxib asolubility and bioavailability
MENNINI, NATASCIA;FURLANETTO, SANDRA;BRAGAGNI, MARCO;GHELARDINI, CARLA;DI CESARE MANNELLI, LORENZO;MURA, PAOLA ANGELA
2014
Abstract
A micellar formulation based on the use of an amphiphilic derivative of chitosan (quaternary-ammonium-palmitoyl-glycol-chitosan, GCPQ) has been succesfully developed to improve the celecoxib solubility and therapeutic effectiveness.
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