Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine residues of mannose for DC targeting and one residue of an immunogenic mimetic of a carbohydrate melanoma associated antigen. The immunological assays demonstrated that the glycodendron 5 is able to induce human immature DC activation in terms of a phenotype expression of co-stimulatory molecules expression and MHCII. Furthermore, DCs activated by the glycodendron 5 stimulate T lymphocytes to proliferate in a mixed lymphocytes reaction (MLR).

Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic / Renato Ribeiro-Viana;Elena Bonechi;Javier Rojo;Clara Ballerini;Giuseppina Comito;Barbara Richichi;Cristina Nativi. - In: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1860-5397. - STAMPA. - 10:(2014), pp. 1317-1324. [10.3762/bjoc.10.133]

Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic

BONECHI, ELENA;BALLERINI, CLARA;COMITO, GIUSEPPINA;RICHICHI, BARBARA;NATIVI, CRISTINA
2014

Abstract

Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine residues of mannose for DC targeting and one residue of an immunogenic mimetic of a carbohydrate melanoma associated antigen. The immunological assays demonstrated that the glycodendron 5 is able to induce human immature DC activation in terms of a phenotype expression of co-stimulatory molecules expression and MHCII. Furthermore, DCs activated by the glycodendron 5 stimulate T lymphocytes to proliferate in a mixed lymphocytes reaction (MLR).
2014
10
1317
1324
Renato Ribeiro-Viana;Elena Bonechi;Javier Rojo;Clara Ballerini;Giuseppina Comito;Barbara Richichi;Cristina Nativi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/927541
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