District disability, fatigue and mood disorders as determinants of health related quality of life in patients with systemic sclerosis.

The significant direct determinants of SPI were found to be FACIT-F (B = –0.61; t = –8.26; P < 0.001) and HAMIS (B = –0.20; t = –2.77; P < 0.001). HAQ, HADS-D and HADS-A were not significantly associated with SPI of SF36, thus they were not included in the final model, that accounted for 43.7% of the variance in SPI of SF36.The significant determinants of SMI were FACIT-F (B = –0.25; t = –3.46; P = 0.001), COPE-NIV Avoidance Strategies subscale, (B = –0.17; t = –2.44; P = 0.016) and HADS-A (B = –0.49; t = –6.25; P < 0.001). The final model accounted for 52.8% of the variance in SMI of SF36. As HADS-A contributed significantly in the prediction of SMI of SF-36, its independent determinants (mouth disability, self-esteem and social support coping strategy) were included in the final model for SMI as factors indirectly affecting SMI (by increasing anxiety).