We report here that the established anticancer ruthenium(m) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.
NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels / S Pillozzi; L Gasparoli; M Stefanini; M Ristori; M D'Amico; E Alessio; F Scaletti; A Becchetti; A Arcangeli; L Messori. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - STAMPA. - 43:(2014), pp. 12150-12150. [10.1039/C4DT01356E]
NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels
PILLOZZI, SERENA;GASPAROLI, LUCA;D'AMICO, MASSIMO;SCALETTI, FEDERICA;ARCANGELI, ANNAROSA;MESSORI, LUIGI
2014
Abstract
We report here that the established anticancer ruthenium(m) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.
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