We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.
A class of pyrrole derivatives endowed with analgesic/anti- inflammatory activity / Battilocchio C; Poce G; Alfonso S; Porretta GC; Consalvi S; Sautebin L; Pace S; Rossi A; Ghelardini C; Di Cesare Mannelli L; Schenone S; Giordani A; Di Francesco L; Patrignani P; Biava M. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 21:(2013), pp. 3695-3701. [10.1016/j.bmc.2013.04.031]
A class of pyrrole derivatives endowed with analgesic/anti- inflammatory activity
GHELARDINI, CARLA;DI CESARE MANNELLI, LORENZO;
2013
Abstract
We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.
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