The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.

VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort / E. Lastraioli;L. Boni;M.R. Romoli;S. Crescioli;A. Taddei;S. Beghelli;A. Tomezzoli;C. Vindigni;L. Saragoni;L. Messerini;M. Bernini;L. Bencini;E. Giommoni;G. Freschi;F. Di Costanzo;A. Scarpa;P. Morgagni;M. Farsi;F. Roviello;G. De Manzoni;P. Bechi;A. Arcangeli. - In: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0748-7983. - ELETTRONICO. - 40:(2014), pp. 1291-1298. [10.1016/j.ejso.2014.03.028]

VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort.

LASTRAIOLI, ELENA;TADDEI, ANTONIO;MESSERINI, LUCA;FRESCHI, GIANCARLO;BECHI, PAOLO;ARCANGELI, ANNAROSA
2014

Abstract

The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.
2014
40
1291
1298
Goal 3: Good health and well-being for people
E. Lastraioli;L. Boni;M.R. Romoli;S. Crescioli;A. Taddei;S. Beghelli;A. Tomezzoli;C. Vindigni;L. Saragoni;L. Messerini;M. Bernini;L. Bencini;E. Giommoni;G. Freschi;F. Di Costanzo;A. Scarpa;P. Morgagni;M. Farsi;F. Roviello;G. De Manzoni;P. Bechi;A. Arcangeli
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/969322
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