VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort.

Lastraioli, Elena; Boni, Luca; Romoli, Maria Raffaella; Crescioli, Silvia; Taddei, Antonio; Beghelli, S.; Tomezzoli, A.; Vindigni, C.; Saragoni, L.; Messerini, Luca; Bernini, M.; Bencini, L.; Giommoni, E.; Freschi, Giancarlo; Di Costanzo, F.; Scarpa, A.; Morgagni, P.; Farsi, M.; Roviello, F.; De Manzoni, G.; Bechi, Paolo; Arcangeli, Annarosa

doi:10.1016/j.ejso.2014.03.028

The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.

VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort / E. Lastraioli, L. Boni, M.R. Romoli, S. Crescioli, A. Taddei, S. Beghelli, A. Tomezzoli, C. Vindigni, L. Saragoni, L. Messerini, M. Bernini, L. Bencini, E. Giommoni, G. Freschi, F. Di Costanzo, A. Scarpa, P. Morgagni, M. Farsi, F. Roviello, G. De Manzoni, et al.. - In: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0748-7983. - ELETTRONICO. - 40:(2014), pp. 1291-1298. [10.1016/j.ejso.2014.03.028]