ENO1-specific Th17 cells have a specific anti-cancer effector function in PC patients, and that there are decreased levels of these cells in cancer compared to healthy mucosa. Conversely, there are elevated levels of ENO1-specific Tregs in PC patients which lead to inhibition of the antigen-specific effector T cells, thus highlighting a possible role in promoting PC progression
Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions / Amedei A; Niccolai E; Benagiano M; Della Bella C; Cianchi F; Bechi P; Taddei A; Bencini L; Farsi M; Cappello P; Prisco D; Novelli F; D'Elios MM. - In: CANCER IMMUNOLOGY, IMMUNOTHERAPY. - ISSN 0340-7004. - ELETTRONICO. - 62:(2013), pp. 1249-1260. [10.1007/s00262-013-1429-3]
Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions.
AMEDEI, AMEDEO;NICCOLAI, ELENA;Della Bella C;CIANCHI, FABIO;BECHI, PAOLO;TADDEI, ANTONIO;PRISCO, DOMENICO;D'ELIOS, MARIO MILCO
2013
Abstract
ENO1-specific Th17 cells have a specific anti-cancer effector function in PC patients, and that there are decreased levels of these cells in cancer compared to healthy mucosa. Conversely, there are elevated levels of ENO1-specific Tregs in PC patients which lead to inhibition of the antigen-specific effector T cells, thus highlighting a possible role in promoting PC progression
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