Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.

Development of human striatal anlagen after transplantation in a patient with Huntington's disease / P. Gallina; M. Paganini; L. Lombardini; R. Saccardi; M. Marini; M.T. De Cristofaro; P. Pinzani; F. Salvianti; C. Crescioli; A. Di Rita; S. Bucciantini; C. Mechi; E. Sarchielli; M. Moretti; S. Piacentini; G. Gritti; A. Bosi; S. Sorbi; G. Orlandini; G.B. Vannelli; N. Di Lorenzo. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - STAMPA. - 213:(2008), pp. 241-244.

Development of human striatal anlagen after transplantation in a patient with Huntington's disease.

GALLINA, PASQUALE;MARINI, MIRCA;PINZANI, PAMELA;SARCHIELLI, ERICA;PIACENTINI, SILVIA;GRITTI, GAETANO;BOSI, ALBERTO;SORBI, SANDRO;ORLANDINI, GIOVANNI;VANNELLI, GABRIELLA;DI LORENZO, NICOLA
2008

Abstract

Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.
2008
213
241
244
P. Gallina; M. Paganini; L. Lombardini; R. Saccardi; M. Marini; M.T. De Cristofaro; P. Pinzani; F. Salvianti; C. Crescioli; A. Di Rita; S. Bucciantini...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/980792
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