| Nome |
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Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform, file e398c37d-028e-179a-e053-3705fe0a4cff
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365
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DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit., file e398c378-9386-179a-e053-3705fe0a4cff
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313
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In silico strategies for the rational design, synthesis, and biological evaluation of ligands targeting macromolecules of pharmaceutical interest, file e398c380-dbb1-179a-e053-3705fe0a4cff
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265
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Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX), file e398c380-cf03-179a-e053-3705fe0a4cff
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235
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Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights, file e398c37e-50c3-179a-e053-3705fe0a4cff
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167
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Solid state and solution study on the formation of inorganic anion complexes with a series of tetrazine-based ligands, file e398c37e-6e13-179a-e053-3705fe0a4cff
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165
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Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition, file e398c381-d57a-179a-e053-3705fe0a4cff
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154
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β3-adrenoreceptor activity limits apigenin efficacy in ewing sarcoma cells: A dual approach to prevent cell survival, file e398c37e-3286-179a-e053-3705fe0a4cff
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151
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From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction, file e398c380-cdc3-179a-e053-3705fe0a4cff
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137
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Tales of the unexpected: The case of zirconium(IV) complexes with desferrioxamine, file e398c37e-2a6c-179a-e053-3705fe0a4cff
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127
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Design, synthesis and binding affinity of new nicotinic ligands, file e398c378-931b-179a-e053-3705fe0a4cff
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115
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Cation, anion and ion-pair complexes with a G-3 poly(ethylene imine) dendrimer in aqueous solution, file e398c37c-5cd0-179a-e053-3705fe0a4cff
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101
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Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation, file e398c380-c9c5-179a-e053-3705fe0a4cff
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89
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2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents., file e398c37d-14ec-179a-e053-3705fe0a4cff
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85
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Role of the Benzodioxole Group in the Interactions between the Natural Alkaloids Chelerythrine and Coptisine and the Human Telomeric G-Quadruplex DNA. A Multiapproach Investigation, file e398c380-d365-179a-e053-3705fe0a4cff
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77
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Sensing Zn2+ in aqueous solution with a fluorescent scorpiand macrocyclic ligand decorated with an anthracene bearing tail, file e398c37f-6513-179a-e053-3705fe0a4cff
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67
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Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives bearing a sulfonamide moiety show single-digit nanomolar-to-subnanomolar inhibition constants against the tumor-associated human carbonic anhydrases IX and XII, file e398c37f-bc87-179a-e053-3705fe0a4cff
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65
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Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy, file e398c380-f9c5-179a-e053-3705fe0a4cff
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62
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Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX), file e398c380-fa16-179a-e053-3705fe0a4cff
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55
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Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies, file e398c382-2163-179a-e053-3705fe0a4cff
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55
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Computationally enhanced X-ray diffraction analysis of a gold(III) complex interacting with the human telomeric DNA G-quadruplex. Unravelling non-unique ligand positioning, file 33a6fd13-3600-4236-b328-8b12dd9ed771
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52
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Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies, file e398c380-ceec-179a-e053-3705fe0a4cff
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50
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Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as AMPA receptor antagonists., file e398c378-9380-179a-e053-3705fe0a4cff
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48
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Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform, file e398c380-fbf8-179a-e053-3705fe0a4cff
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42
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Synthesis, biological evaluation and docking studies of casuarine analogs: effects of structural modifications at ring B on inhibitory activity towards glucoamylase, file e398c378-bb40-179a-e053-3705fe0a4cff
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32
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Insights into docking and scoring neuronal 42 nicotinic receptor agonists using Molecular Dynamics simulations and QM/MM calculations, file e398c378-a6cc-179a-e053-3705fe0a4cff
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31
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Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin, file e398c381-aab2-179a-e053-3705fe0a4cff
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30
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4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles., file e398c380-cc5c-179a-e053-3705fe0a4cff
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29
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Enhanced curcumin permeability by SLN formulation: The PAMPA approach, file e398c380-f2ac-179a-e053-3705fe0a4cff
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22
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Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights, file dd05094f-b1fd-49da-852e-5493156e70ea
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19
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Binding of berberine and sanguinarine with G-quadruplex and duplex DNA revealed by surface-enhanced Raman spectroscopy, file e398c37f-b7dd-179a-e053-3705fe0a4cff
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16
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Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors, file fde27e21-231a-439b-b592-f86f5bbe1cb9
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15
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Pyrrolyl and Indolyl alpha-gamma-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII, file 533f6d26-ce9d-4add-b0ca-f5711eacfcc0
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7
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Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis, file 863abaf9-ff8e-4f92-9ee5-e7c63970cb37
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7
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Selective binding and fluorescence sensing of diphosphate in H2O via Zn2+-induced allosteric regulation of the receptor structure, file e398c378-ca6c-179a-e053-3705fe0a4cff
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7
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Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors, file 467126b4-9137-41e4-8b4c-1c0067907492
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6
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New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors, file e398c381-ca8b-179a-e053-3705fe0a4cff
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5
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Enhanced curcumin permeability by SLN formulation: The PAMPA approach, file e398c37a-51f8-179a-e053-3705fe0a4cff
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4
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Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy, file e398c37e-436f-179a-e053-3705fe0a4cff
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4
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Polypharmacology of epacadostat: A potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII, file e398c37e-50c0-179a-e053-3705fe0a4cff
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4
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New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors, file e398c381-08ac-179a-e053-3705fe0a4cff
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4
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Natural Polyphenols Selectively Inhibit β-Carbonic Anhydrase from the Dandruff-Producing Fungus Malassezia globosa: Activity and Modeling Studies, file e398c37d-64f4-179a-e053-3705fe0a4cff
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3
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Tuning the Activity of Zn(II) Complexes in DNA Cleavage: Clues for Design of New Efficient Metallo-Hydrolases, file e398c378-931e-179a-e053-3705fe0a4cff
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2
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Modeling and Biological Investigations of an Unusual Behavior of Novel Synthesized Acridine- Based Polyamine Ligands in the Binding of Double Helix and G-Quadruplex DNA, file e398c378-c717-179a-e053-3705fe0a4cff
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2
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Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies, file e398c37b-8d31-179a-e053-3705fe0a4cff
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2
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|
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles., file e398c37e-4378-179a-e053-3705fe0a4cff
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2
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Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents, file e398c37f-bbe1-179a-e053-3705fe0a4cff
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2
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Leveraging SARS-CoV-2 Main Protease (Mpro) for COVID-19 Mitigation with Selenium-Based Inhibitors, file faa729ab-77f1-4d91-bc68-a48b2a511ada
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2
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A novel selective GABA-A alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents., file e398c378-9893-179a-e053-3705fe0a4cff
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1
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A highly pH-sensitive Zn(II) chemosensor, file e398c378-b946-179a-e053-3705fe0a4cff
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1
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The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1, file e398c378-da4d-179a-e053-3705fe0a4cff
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1
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Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation, file e398c37a-51fa-179a-e053-3705fe0a4cff
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1
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Antagonism/agonism modulation to build novel antihypertensives selectively triggering I1-imidazoline receptor activation, file e398c37b-9419-179a-e053-3705fe0a4cff
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1
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Assessment of human telomeric G-quadruplex structures using surface-enhanced Raman spectroscopy, file e398c37b-975c-179a-e053-3705fe0a4cff
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1
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Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations, file e398c37b-988a-179a-e053-3705fe0a4cff
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1
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Interactions of selected gold(III) complexes with
DNA G quadruplexes, file e398c37b-994c-179a-e053-3705fe0a4cff
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1
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Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa, file e398c37b-99e3-179a-e053-3705fe0a4cff
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1
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Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding, file e398c37c-007e-179a-e053-3705fe0a4cff
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1
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Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates, file e398c37c-9937-179a-e053-3705fe0a4cff
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1
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[Au(9-methylcaffein-8-ylidene)2]+/DNA Tel23 System: Solution, Computational, and Biological Studies, file e398c37c-9c9e-179a-e053-3705fe0a4cff
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1
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Role of the Benzodioxole Group in the Interactions between the Natural Alkaloids Chelerythrine and Coptisine and the Human Telomeric G-Quadruplex DNA. A Multiapproach Investigation, file e398c37c-afe2-179a-e053-3705fe0a4cff
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1
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Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties, file e398c37c-d717-179a-e053-3705fe0a4cff
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1
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Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis, file e398c37e-468c-179a-e053-3705fe0a4cff
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1
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Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex, file e398c37e-a922-179a-e053-3705fe0a4cff
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1
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Effect of structure levels on surface-enhanced Raman scattering of human telomeric G-quadruplexes in diluted and crowded media, file e398c37e-a923-179a-e053-3705fe0a4cff
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1
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Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action, file e398c380-4526-179a-e053-3705fe0a4cff
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1
|
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Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies, file e398c380-861d-179a-e053-3705fe0a4cff
|
1
|
|
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy, file e398c380-8629-179a-e053-3705fe0a4cff
|
1
|
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Selenols: a new class of carbonic anhydrase inhibitors, file e398c380-dd3a-179a-e053-3705fe0a4cff
|
1
|
| Totale |
3.320 |