CHITI, FABRIZIO
 Distribuzione geografica
Continente #
NA - Nord America 4.034
EU - Europa 2.116
AS - Asia 835
AF - Africa 74
OC - Oceania 59
SA - Sud America 49
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.168
Nazione #
US - Stati Uniti d'America 3.920
FR - Francia 432
IT - Italia 377
CN - Cina 329
GB - Regno Unito 263
DE - Germania 207
IE - Irlanda 185
IN - India 135
PL - Polonia 133
NL - Olanda 115
CA - Canada 102
VN - Vietnam 102
ES - Italia 89
JP - Giappone 74
AU - Australia 57
ZA - Sudafrica 55
BE - Belgio 48
CZ - Repubblica Ceca 35
RU - Federazione Russa 34
FI - Finlandia 31
HK - Hong Kong 30
CL - Cile 27
UA - Ucraina 27
IR - Iran 24
SE - Svezia 23
PT - Portogallo 22
KR - Corea 20
RO - Romania 19
SG - Singapore 19
DK - Danimarca 17
AE - Emirati Arabi Uniti 16
IL - Israele 16
BR - Brasile 13
MX - Messico 12
PH - Filippine 12
CH - Svizzera 10
IQ - Iraq 10
SA - Arabia Saudita 9
AT - Austria 8
ID - Indonesia 8
LT - Lituania 8
TW - Taiwan 8
EG - Egitto 7
NG - Nigeria 7
NO - Norvegia 7
GR - Grecia 6
AR - Argentina 5
MY - Malesia 5
GH - Ghana 4
HU - Ungheria 4
MO - Macao, regione amministrativa speciale della Cina 4
PK - Pakistan 3
TR - Turchia 3
BY - Bielorussia 2
EE - Estonia 2
LV - Lettonia 2
MT - Malta 2
NZ - Nuova Zelanda 2
PE - Perù 2
SI - Slovenia 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
BD - Bangladesh 1
BG - Bulgaria 1
CO - Colombia 1
EU - Europa 1
HR - Croazia 1
JO - Giordania 1
KH - Cambogia 1
LU - Lussemburgo 1
MA - Marocco 1
OM - Oman 1
QA - Qatar 1
RS - Serbia 1
SR - Suriname 1
TM - Turkmenistan 1
Totale 7.168
Città #
Fairfield 377
Santa Cruz 294
Buffalo 278
Houston 263
Ashburn 258
Seattle 241
Cambridge 219
Woodbridge 215
Dublin 179
Warsaw 119
Wilmington 110
Florence 99
Ann Arbor 84
Dong Ket 84
Chicago 60
Beijing 58
Boardman 52
Mountain View 52
Wuhan 49
University Park 45
Las Vegas 42
New York 42
Muizenberg 41
Clearwater 36
Shanghai 35
Los Angeles 34
Phoenix 33
Bengaluru 30
Ottawa 27
Council Bluffs 26
Dallas 25
Rome 23
San Diego 23
Fleming Island 22
Henderson 21
Memphis 21
Toronto 21
Helsinki 20
Minneapolis 19
Brussels 18
Guangzhou 17
London 17
Riva 17
Barcelona 15
Paris 15
Atlanta 14
Baltimore 14
Lake Forest 14
Madison 14
San Francisco 14
Tokyo 14
Bordeaux 13
Bremen 13
Singapore 13
Southampton 13
Hangzhou 12
Milan 12
Austin 11
Central 11
Pisa 11
San Jose 11
Amsterdam 10
Des Moines 10
Hanoi 10
Sydney 10
Utrecht 10
Washington 10
Brooklyn 9
Changsha 9
Irvine 9
Kansas City 9
Munich 9
Nanjing 9
Padova 9
Anghiari 8
Castelliri 8
Delhi 8
Duncan 8
Leeds 8
Leiden 8
Leuven 8
Melbourne 8
Napoli 8
Saint Petersburg 8
Turin 8
Boston 7
Boulder 7
Easton 7
Hamilton 7
Herndon 7
Hobart 7
Rhoon 7
Rivne 7
Santiago 7
Sint Odilienberg 7
Taipei 7
Alexandria 6
Andover 6
Bangalore 6
Berlin 6
Totale 4.292
Nome #
Protein misfolding, amyloid formation, and human disease: A summary of progress over the last decade, file e398c381-5047-179a-e053-3705fe0a4cff 624
A causative link between the structure of aberrant protein oligomers and their toxicity, file e398c378-b3de-179a-e053-3705fe0a4cff 475
Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload, file e398c37c-38cf-179a-e053-3705fe0a4cff 401
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers, file e398c381-2859-179a-e053-3705fe0a4cff 392
Molecular links between aberrant protein oligomers and neurodegeneration in Alzheimer’s disease, file e398c37b-a5d6-179a-e053-3705fe0a4cff 212
Patterns of cell death triggered in two different cell lines by HypF-N prefibrillar aggregates., file e398c378-955b-179a-e053-3705fe0a4cff 210
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity, file e398c37b-a4f1-179a-e053-3705fe0a4cff 195
The contribution of acidic residues to the conformational stability of common-type acylphosphatase, file e398c378-9199-179a-e053-3705fe0a4cff 185
The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis, file e398c379-5353-179a-e053-3705fe0a4cff 172
Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions, file e398c37b-e1f9-179a-e053-3705fe0a4cff 165
Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia, file e398c37b-d25c-179a-e053-3705fe0a4cff 164
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells, file e398c37b-a4b0-179a-e053-3705fe0a4cff 162
Small molecule protein binding to correct cellular folding or stabilize the native state against misfolding and aggregation, file ab1d5478-d4c6-40c5-9842-a7b546304310 157
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes, file e398c37d-de56-179a-e053-3705fe0a4cff 150
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases, file e398c37b-9ff3-179a-e053-3705fe0a4cff 148
Probing the origin of the toxicity of oligomeric aggregates of α-synuclein with antibodies, file e398c37e-624e-179a-e053-3705fe0a4cff 147
Insight into the structure of amyloid fibrils from the analysis of globular proteins, file e398c37a-405e-179a-e053-3705fe0a4cff 145
Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations, file e398c37b-db9c-179a-e053-3705fe0a4cff 145
Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation, file e398c37e-944e-179a-e053-3705fe0a4cff 143
Capturing Aβ42 aggregation in the cell, file e398c37d-fee9-179a-e053-3705fe0a4cff 132
Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils, file e398c37a-4b72-179a-e053-3705fe0a4cff 129
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells, file e398c378-f70d-179a-e053-3705fe0a4cff 128
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases, file b874e5ce-3aa3-4310-99d2-e82ed99c889b 126
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells, file e398c37b-d4e5-179a-e053-3705fe0a4cff 121
Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy, file e398c37b-dfe1-179a-e053-3705fe0a4cff 121
Chaperones in Neurodegeneration, file e398c37a-701d-179a-e053-3705fe0a4cff 117
A computational approach for identifying the chemical factors involved in the glycosaminoglycans-mediated acceleration of amyloid fibril formation, file e398c37a-42d6-179a-e053-3705fe0a4cff 116
Aggregation propensity of the human proteome, file e398c37a-3f88-179a-e053-3705fe0a4cff 106
Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases, file e398c37e-9cdd-179a-e053-3705fe0a4cff 106
The N-terminal helix controls the transition between the soluble and amyloid states of an FF domain., file e398c37a-5643-179a-e053-3705fe0a4cff 104
Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine, file 96185b7c-60c4-427b-aad6-d7dd27eeff43 103
Backbone NMR assignments of HypF-N under conditions generating toxic and non-toxic oligomers, file e398c37d-a842-179a-e053-3705fe0a4cff 100
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43, file 3c046775-2499-4dfb-8ac3-79be4811ffad 97
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity, file e398c37a-3ffb-179a-e053-3705fe0a4cff 94
Quantification of the Relative Contributions of Loss-of function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies, file e398c37b-a4ab-179a-e053-3705fe0a4cff 94
Probing conformational changes of monomeric transthyretin with second derivative fluorescence, file e398c37f-e67b-179a-e053-3705fe0a4cff 91
Toxic HypF-N oligomers selectively bind the plasma membrane to impair cell adhesion capability, file e398c37e-99f9-179a-e053-3705fe0a4cff 87
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells, file e398c381-6775-179a-e053-3705fe0a4cff 78
Nanoscopic insights into the surface conformation of neurotoxic amyloid b oligomers, file e398c37f-83ec-179a-e053-3705fe0a4cff 72
Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity, file e398c37f-015a-179a-e053-3705fe0a4cff 71
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism, file e398c380-3498-179a-e053-3705fe0a4cff 71
Urea titration of a lipase from Pseudomonas sp. reveals four different conformational states, with a stable partially folded state explaining its high aggregation propensity, file 6e45af78-546e-4636-8ec4-1687ea0ee4b3 68
Soluble Prion peptide 107–120 protects neuroblastoma SH-SY5Y cells against oligomers associated with Alzheimer’s disease, file e398c380-1e71-179a-e053-3705fe0a4cff 68
Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors, file 469d176f-7b4a-40b4-b914-7dd8103eb913 61
Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity, file e398c37d-a844-179a-e053-3705fe0a4cff 59
Thermodynamics and kinetics of folding of common type acylphosphatase, file e398c378-8b7d-179a-e053-3705fe0a4cff 48
Homage to Chris Dobson, file e398c380-1538-179a-e053-3705fe0a4cff 47
Biophysical characterization of full length TAR DNA-Binding Protein (TDP-43) phase separation, file 5a9caa20-b6ef-4151-b987-7fb182b2d367 44
Single particle tracking to study the binding of protein misfolded oligomer to membrane ganglioside GM1, file e398c37b-9f1f-179a-e053-3705fe0a4cff 43
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers, file e398c37c-aeff-179a-e053-3705fe0a4cff 43
Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers, file e398c381-814f-179a-e053-3705fe0a4cff 38
Cloning, expression and characterization of a new human LMW-PTP isoform originating by alternative splicing, file e398c378-950c-179a-e053-3705fe0a4cff 35
Conversion of the Native N-Terminal Domain of TDP-43 into a Monomeric Alternative Fold with Lower Aggregation Propensity, file 71778391-8e07-4058-9703-be2b1cc33e0b 26
Looking for residues involved in the muscle acylphosphatase catalytic mechanism and structural stabilization: role of Asn41, Ther42 and Thr46, file e398c378-b2ce-179a-e053-3705fe0a4cff 26
Distinct responses of human peripheral blood cells to different misfolded protein oligomers, file 1220483e-e090-4118-8b42-d3cbf0349667 20
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species, file 37ec0f86-dbc8-4919-8ac7-b0287cffde83 20
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine, file 51e5654f-4b60-4086-9db0-2a4a10f8bdbb 20
Full-length TDP-43 and its C-terminal domain form filaments in vitro having non-amyloid properties, file 7dbd0e4b-007c-492d-8f12-adff1379560d 20
Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans, file 7cbac64d-4a11-41d1-a2ca-8dba546ab1ff 19
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine, file e398c37d-7b95-179a-e053-3705fe0a4cff 19
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic, file 935afeee-5831-47a3-b6fb-4bdce5d92630 17
The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes, file effc07af-98c5-47c6-92ff-2f0c53afa22a 8
Alzheimer Disease detection from Raman spectroscopy of the cerebrospinal fluid via topological machine learning, file 93d600df-8e24-49e5-98b1-175d841d1431 7
Studying the trafficking of labeled trodusquemine and its application as nerve marker for light-sheet and expansion microscopy, file a435e799-e1cd-4c9d-a713-bf416b0f6eae 7
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature, file d6b5a264-6733-4a2a-8fa9-1b422ab290ee 7
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine, file e398c381-7c02-179a-e053-3705fe0a4cff 7
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes, file 6671bc9e-dcb1-42fc-beae-23ebc34dcc29 5
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF, file baad6f55-8e06-4e1b-b972-9b4273d9e8d8 2
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers, file e398c378-bf91-179a-e053-3705fe0a4cff 2
Glycosaminoglycans (GAGs) Suppress the Toxicity of HypF-N Prefibrillar Aggregates, file e398c378-db1b-179a-e053-3705fe0a4cff 2
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers, file e398c378-db1c-179a-e053-3705fe0a4cff 2
The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies, file e398c37b-1be1-179a-e053-3705fe0a4cff 2
Putative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort, file 26f0141a-e2c6-4572-8fb0-610324cd714b 1
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells, file e398c378-b3fe-179a-e053-3705fe0a4cff 1
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro, file e398c378-df1b-179a-e053-3705fe0a4cff 1
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains, file e398c378-e3a1-179a-e053-3705fe0a4cff 1
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity, file e398c378-f3b2-179a-e053-3705fe0a4cff 1
A Complex Equilibrium among Partially Unfolded Conformations in Monomeric Transthyretin, file e398c378-fb29-179a-e053-3705fe0a4cff 1
Protein misfolding, amyloid formation, and human disease: A summary of progress over the last decade, file e398c37c-8be3-179a-e053-3705fe0a4cff 1
Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine, file e398c380-77e3-179a-e053-3705fe0a4cff 1
Totale 7.456
Categoria #
all - tutte 14.704
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 14.704


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019481 0 0 0 0 0 0 0 0 77 103 143 158
2019/20201.182 110 99 59 93 137 120 104 99 133 72 98 58
2020/2021922 75 95 38 78 81 70 57 59 88 74 108 99
2021/20221.673 131 58 68 123 318 107 105 147 97 68 318 133
2022/20231.872 67 89 304 269 127 155 281 155 145 83 155 42
2023/2024936 46 43 88 98 96 69 239 158 99 0 0 0
Totale 7.456