| Nome |
# |
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4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs, file e398c378-9834-179a-e053-3705fe0a4cff
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332
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Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity, file e398c378-9bf3-179a-e053-3705fe0a4cff
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329
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The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR), file e398c378-9b01-179a-e053-3705fe0a4cff
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275
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Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity, file e398c37d-43d9-179a-e053-3705fe0a4cff
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252
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Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs., file e398c378-9574-179a-e053-3705fe0a4cff
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240
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Central muscarinic antinociception induced by ET-142 and SS-20 in rodents, file e398c378-93f8-179a-e053-3705fe0a4cff
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239
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1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli, file e398c380-3cbc-179a-e053-3705fe0a4cff
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237
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Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers, file e398c37e-9717-179a-e053-3705fe0a4cff
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215
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In vitro characterization of a novel, potent and selective M3 antagonist, file e398c378-973d-179a-e053-3705fe0a4cff
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177
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Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters, file e398c378-9e8e-179a-e053-3705fe0a4cff
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168
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AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES, file e398c378-9d5c-179a-e053-3705fe0a4cff
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156
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Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators, file e398c37f-279b-179a-e053-3705fe0a4cff
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105
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Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death, file e398c37f-8e46-179a-e053-3705fe0a4cff
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88
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2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents., file e398c37d-14ec-179a-e053-3705fe0a4cff
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87
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Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y, file e398c37f-54c1-179a-e053-3705fe0a4cff
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75
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6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers, file e398c37f-6be3-179a-e053-3705fe0a4cff
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72
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Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities, file e398c380-df05-179a-e053-3705fe0a4cff
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63
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Synthesis of functionalised organochalcogenides and in vitro evaluation of their antioxidant activity, file e398c381-7dbd-179a-e053-3705fe0a4cff
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60
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Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine, file e398c37f-8357-179a-e053-3705fe0a4cff
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56
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An easy one-step procedure for the synthesis of novel beta-functionalised tellurides, file e398c381-9492-179a-e053-3705fe0a4cff
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47
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Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities, file e398c380-cafe-179a-e053-3705fe0a4cff
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42
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New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators, file e398c381-fdd9-179a-e053-3705fe0a4cff
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38
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Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4-Substituted Quinazoline Derivatives, file e398c382-5434-179a-e053-3705fe0a4cff
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38
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Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers, file e398c380-ffce-179a-e053-3705fe0a4cff
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34
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Recent advances in the discovery of Nicotinic acetylcholine
receptor allosteric modulators, file 7283ff43-3a9b-4ec1-b5bc-45860522feec
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29
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New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells, file d61018d2-0fac-4444-a72e-7ce3d8bf5128
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28
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Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers, file e398c381-091f-179a-e053-3705fe0a4cff
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19
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Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents, file e398c380-feea-179a-e053-3705fe0a4cff
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18
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The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance, file 7edf0d36-80fa-4012-a3db-41432586bc26
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17
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Dual HDAC–BRD4 inhibitors endowed with antitumor and antihyperalgesic activity, file e398c382-38c1-179a-e053-3705fe0a4cff
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16
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Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators, file e398c380-fbe7-179a-e053-3705fe0a4cff
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15
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Cholinergic Receptor Binding Profile of Hypericum perforatum L. and its Active Constituents, file 042b3c16-87f1-47a2-a4a0-89db046ca29a
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10
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Simultaneous Degradation Study of Isomers in Human Plasma by HPLC-MS/MS and Application of LEDA Algorithm for Their Characterization, file 93fb6d7b-98e9-4f9d-b7bb-8b59c9b9c907
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8
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Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR), file e398c382-2360-179a-e053-3705fe0a4cff
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8
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New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors, file e398c381-ca8b-179a-e053-3705fe0a4cff
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6
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Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR), file e398c37c-8812-179a-e053-3705fe0a4cff
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4
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Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities, file e398c37c-db75-179a-e053-3705fe0a4cff
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4
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New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors, file e398c381-08ac-179a-e053-3705fe0a4cff
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4
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Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers, file 77de89f1-228f-4ceb-9a42-d83a3b7b1d50
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3
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Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters, file e398c378-f5fa-179a-e053-3705fe0a4cff
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3
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Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents, file e398c37c-9567-179a-e053-3705fe0a4cff
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3
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EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues, file e398c37e-b8dc-179a-e053-3705fe0a4cff
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3
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Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR), file e398c382-1812-179a-e053-3705fe0a4cff
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3
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The piperazine scaffold for novel drug discovery efforts: the evidence to date, file dbed17ad-3999-4b90-bda4-fcfe329d3603
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2
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Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring, file e398c378-e648-179a-e053-3705fe0a4cff
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2
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Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy, file e398c379-e9c6-179a-e053-3705fe0a4cff
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2
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New quinoline derivatives as nicotinic receptor modulators, file e398c37a-214f-179a-e053-3705fe0a4cff
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2
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VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE, file e398c37b-35b4-179a-e053-3705fe0a4cff
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2
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Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents, file e398c37b-93eb-179a-e053-3705fe0a4cff
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2
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Application of LEDA algorithm for the recognition of P-glycoprotein and Carbonic Anhydrase hybrid inhibitors and evaluation of their plasma stability by HPLC-MS/MS analysis, file c2198143-c274-47d1-a284-f5eb4229f887
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1
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Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain, file e398c378-98a4-179a-e053-3705fe0a4cff
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1
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N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors, file e398c378-ab2c-179a-e053-3705fe0a4cff
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1
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New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR), file e398c378-e063-179a-e053-3705fe0a4cff
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1
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Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235, file e398c379-688d-179a-e053-3705fe0a4cff
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1
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Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity, file e398c379-b1d8-179a-e053-3705fe0a4cff
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1
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Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs, file e398c379-e966-179a-e053-3705fe0a4cff
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1
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Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs, file e398c379-eb93-179a-e053-3705fe0a4cff
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1
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Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers., file e398c37b-11e4-179a-e053-3705fe0a4cff
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1
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|
In vitro and in silico analysis of the vascular effects
of asymmetrical N,N-bis(alkanol)amine aryl esters, novel
multidrug resistance-reverting agents, file e398c37b-1a94-179a-e053-3705fe0a4cff
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1
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Carbachol dimers as homobivalent modulators of muscarinic receptors, file e398c37b-1e6e-179a-e053-3705fe0a4cff
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1
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Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers, file e398c37c-1fce-179a-e053-3705fe0a4cff
|
1
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|
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators, file e398c37e-36dd-179a-e053-3705fe0a4cff
|
1
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Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors, file e398c37e-937c-179a-e053-3705fe0a4cff
|
1
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Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors, file e398c37f-f275-179a-e053-3705fe0a4cff
|
1
|
| Totale |
3.653 |