DEI, SILVIA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 7.531
EU - Europa 4.979
AS - Asia 669
AF - Africa 21
SA - Sud America 5
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 1
Totale 13.209
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 7.508
PL - Polonia 1.514
IE - Irlanda 867
SE - Svezia 803
IT - Italia 618
UA - Ucraina 270
DE - Germania 212
VN - Vietnam 198
FI - Finlandia 183
HK - Hong Kong 173
GB - Regno Unito 134
CN - Cina 127
AT - Austria 124
CH - Svizzera 73
BE - Belgio 69
JO - Giordania 44
TR - Turchia 43
ES - Italia 29
SG - Singapore 29
FR - Francia 27
KR - Corea 24
CA - Canada 23
NL - Olanda 23
IN - India 21
SC - Seychelles 13
RO - Romania 12
CZ - Repubblica Ceca 5
HR - Croazia 5
MU - Mauritius 4
DZ - Algeria 3
HU - Ungheria 3
JP - Giappone 3
RU - Federazione Russa 3
AR - Argentina 2
EU - Europa 2
TW - Taiwan 2
A1 - Anonimo 1
BG - Bulgaria 1
CL - Cile 1
EC - Ecuador 1
GR - Grecia 1
IL - Israele 1
IR - Iran 1
LB - Libano 1
LU - Lussemburgo 1
LV - Lettonia 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PE - Perù 1
PH - Filippine 1
RS - Serbia 1
UZ - Uzbekistan 1
Totale 13.209
Salva come PNG Salva come JPEG
Città #
Warsaw 1.509
Fairfield 1.038
Chandler 1.004
Dublin 863
Ashburn 589
Woodbridge 472
Cambridge 468
Jacksonville 419
Houston 405
Seattle 393
Wilmington 356
Ann Arbor 244
Princeton 212
Dong Ket 192
Boston 173
Altamura 162
Florence 139
Lawrence 135
Buffalo 102
Beijing 94
Boardman 85
Vienna 82
Bern 71
Medford 70
Brussels 68
San Diego 59
Izmir 38
Falls Church 37
Norwalk 37
Washington 29
Barcelona 27
Hillsboro 24
Milan 24
Andover 23
Guangzhou 22
Phoenix 21
Seongnam 20
Frankfurt Am Main 19
Philadelphia 19
Lappeenranta 18
Verona 17
Dearborn 16
Redwood City 16
Rome 16
Toronto 15
Pune 13
London 12
Los Angeles 10
Gavirate 9
Hanover 9
Düsseldorf 8
Auburn Hills 7
Treviglio 7
Groningen 6
Laurel 6
Ottawa 6
Misano Adriatico 5
Siena 5
Genoa 4
Grafing 4
Menlo Park 4
Nanjing 4
Sesto Fiorentino 4
Amherst 3
Budapest 3
Cedar Knolls 3
Edinburgh 3
Leawood 3
Redmond 3
Reggio Emilia 3
San Martino Buon Albergo 3
Scandicci 3
Trumbull 3
Wroclaw 3
Acton 2
Bologna 2
Brno 2
Buenos Aires 2
Campi Bisenzio 2
Capannelle 2
Castelfranco Emilia 2
Chennai 2
Duncan 2
Easton 2
Emmering 2
Giugliano in Campania 2
Helsinki 2
Krakow 2
Lucca 2
Mcallen 2
Miami 2
Montefredane 2
Monza 2
Naaldwijk 2
Napoli 2
Paris 2
Parma 2
Prague 2
Rivoli 2
Romainville 2
Totale 10.050
Salva come PNG Salva come JPEG
Nome #
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 273
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 261
AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES 242
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) 227
Central muscarinic antinociception induced by ET-142 and SS-20 in rodents 223
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 212
In vitro characterization of a novel, potent and selective M3 antagonist 211
Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity 196
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 194
An easy one-step procedure for the synthesis of novel beta-functionalised tellurides 191
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 142
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 136
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 134
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 119
1,3-oxathiolane muscarinic ligands modified at the cationic head. 115
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 113
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 112
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 110
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 108
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 108
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 107
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 107
N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR) 106
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 106
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 106
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 105
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 105
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 104
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 104
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 104
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 102
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 99
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 97
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 97
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 97
The medicinal chemistry of multidrug resistance (MDR) reversing drugs 97
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 93
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli 93
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 93
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 93
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 92
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 90
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 89
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 88
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 88
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 88
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 86
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 86
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 85
Design of novel nicotinic ligands through 3D database searching 85
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 85
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 84
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 84
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 83
Carbachol dimers as homobivalent modulators of muscarinic receptors 83
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 82
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 82
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 82
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 82
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 82
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 82
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 81
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 81
Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone 80
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 80
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents 80
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 78
Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain 78
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 77
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 76
New quinoline derivatives as nicotinic receptor modulators 75
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 75
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 75
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists 74
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF VERAPAMIL ANALOGS WITH RESTRICTED MOLECULAR FLEXIBILITY 73
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 73
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 73
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 73
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 72
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 71
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 71
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 70
Reversal of multidrug resistance by verapamil analogues 70
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 70
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 69
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 69
S-(-)-ET126: a potent and selective M1 antagonist 68
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 67
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 66
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 65
New phenylalkylamines as isoform selective HCN-Channels blockers 65
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 65
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 64
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 64
Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity 63
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 63
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 62
SYNTHESIS AND CARDIOVASCULAR PROPERTIES OF FLUORENYL DERIVATIVES RELATED TO VERAPAMIL 62
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM 60
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding 59
Totale 9.987
Salva come PNG Salva come JPEG
Categoria #
all - tutte 33.617
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.617
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.125 0 0 0 0 0 35 61 28 67 208 396 330
2019/20202.566 207 222 84 231 276 301 252 316 232 161 241 43
2020/20212.042 167 127 120 219 52 255 64 176 160 301 106 295
2021/20221.354 42 183 89 43 37 41 72 76 41 45 294 391
2022/20233.935 342 582 184 294 283 714 571 262 397 35 155 116
2023/2024815 71 173 247 105 109 110 0 0 0 0 0 0
Totale 13.493