DEI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 11.931
EU - Europa 7.496
AS - Asia 1.859
OC - Oceania 114
AF - Africa 67
SA - Sud America 6
Continente sconosciuto - Info sul continente non disponibili 3
Totale 21.476
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Nazione #
US - Stati Uniti d'America 11.899
RU - Federazione Russa 2.412
PL - Polonia 1.515
IE - Irlanda 927
SE - Svezia 805
IT - Italia 681
SG - Singapore 482
HK - Hong Kong 473
CN - Cina 377
UA - Ucraina 270
DE - Germania 265
FI - Finlandia 234
VN - Vietnam 198
IN - India 148
GB - Regno Unito 139
AU - Australia 113
CH - Svizzera 83
TR - Turchia 46
JO - Giordania 44
CI - Costa d'Avorio 42
ID - Indonesia 35
KR - Corea 35
FR - Francia 33
BE - Belgio 31
ES - Italia 30
CA - Canada 28
NL - Olanda 27
RO - Romania 17
SC - Seychelles 13
JP - Giappone 7
DZ - Algeria 6
AT - Austria 5
HR - Croazia 5
MO - Macao, regione amministrativa speciale della Cina 4
MU - Mauritius 4
MX - Messico 4
CZ - Repubblica Ceca 3
HU - Ungheria 3
AR - Argentina 2
DK - Danimarca 2
EG - Egitto 2
EU - Europa 2
IL - Israele 2
MK - Macedonia 2
TW - Taiwan 2
A1 - Anonimo 1
BG - Bulgaria 1
CL - Cile 1
CO - Colombia 1
EC - Ecuador 1
GR - Grecia 1
IR - Iran 1
KZ - Kazakistan 1
LB - Libano 1
LK - Sri Lanka 1
LT - Lituania 1
LU - Lussemburgo 1
LV - Lettonia 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PE - Perù 1
PH - Filippine 1
RS - Serbia 1
UZ - Uzbekistan 1
Totale 21.476
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Città #
Santa Clara 3.553
Warsaw 1.510
Fairfield 1.038
Chandler 1.004
Dublin 923
Ashburn 680
Woodbridge 472
Cambridge 468
Jacksonville 419
Seattle 409
Houston 405
Singapore 374
Wilmington 356
Hong Kong 300
Ann Arbor 244
Princeton 212
Dong Ket 192
Boston 173
Altamura 162
Florence 150
Lawrence 135
Mumbai 127
Melbourne 113
Beijing 110
Boardman 110
Buffalo 102
Bern 71
Shanghai 71
Medford 70
Moscow 68
San Diego 59
Helsinki 51
Munich 46
Kent 43
Abidjan 42
Izmir 38
Falls Church 37
Norwalk 37
Jakarta 35
New York 35
Los Angeles 30
Milan 30
Brussels 29
Washington 29
Guangzhou 28
Barcelona 27
Hillsboro 24
Andover 23
West Jordan 22
Phoenix 21
Lappeenranta 20
Seongnam 20
Frankfurt Am Main 19
Philadelphia 19
Verona 18
Dearborn 16
Redwood City 16
Rome 16
Toronto 16
Pune 13
Yubileyny 13
London 11
Seoul 11
Ottawa 10
Gavirate 9
Düsseldorf 8
Frankfurt am Main 8
Auburn Hills 7
Treviglio 7
Groningen 6
Laurel 6
Romola 6
Tappahannock 6
Misano Adriatico 5
Siena 5
Genoa 4
Grafing 4
Hanover 4
Macao 4
Menlo Park 4
Nanjing 4
Nuremberg 4
Parma 4
Sesto Fiorentino 4
Tokyo 4
Amherst 3
Amsterdam 3
Bologna 3
Budapest 3
Cedar Knolls 3
Edinburgh 3
Iclod 3
Leawood 3
Redmond 3
Reggio Emilia 3
San Martino Buon Albergo 3
San Tan Valley 3
Sassano 3
Scandicci 3
Trumbull 3
Totale 15.083
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Nome #
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 306
AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES 289
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 288
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) 270
Central muscarinic antinociception induced by ET-142 and SS-20 in rodents 250
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 243
In vitro characterization of a novel, potent and selective M3 antagonist 240
Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity 237
An easy one-step procedure for the synthesis of novel beta-functionalised tellurides 231
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 229
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 187
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 181
N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR) 174
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 173
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 166
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 158
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 157
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 153
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli 150
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 150
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 149
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 149
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 148
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 146
1,3-oxathiolane muscarinic ligands modified at the cationic head. 144
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 143
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 143
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 143
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 143
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 142
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 142
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 140
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 139
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 138
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 137
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 135
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 135
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 134
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 133
Carbachol dimers as homobivalent modulators of muscarinic receptors 132
Design of novel nicotinic ligands through 3D database searching 129
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 129
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 127
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 127
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 127
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 126
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 126
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 126
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 125
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 125
The medicinal chemistry of multidrug resistance (MDR) reversing drugs 124
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 122
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 121
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 121
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 121
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 121
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 120
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 120
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 119
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 119
S-(-)-ET126: a potent and selective M1 antagonist 118
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 117
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 117
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 116
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 116
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 116
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 115
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 115
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 114
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 114
Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone 114
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 114
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents 114
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 113
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 113
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 112
New phenylalkylamines as isoform selective HCN-Channels blockers 112
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 112
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 111
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 111
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 111
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 110
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators 110
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 109
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 109
Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain 109
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 109
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 108
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 108
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM 108
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 107
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 107
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 106
New quinoline derivatives as nicotinic receptor modulators 105
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 104
Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity 103
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists 102
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 102
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 101
Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina 101
Totale 13.935
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Categoria #
all - tutte 60.287
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.287
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.546 0 0 0 0 0 301 252 316 232 161 241 43
2020/20212.042 167 127 120 219 52 255 64 176 160 301 106 295
2021/20221.354 42 183 89 43 37 41 72 76 41 45 294 391
2022/20233.764 342 582 184 294 283 714 499 232 382 23 126 103
2023/20241.610 46 162 237 84 98 308 49 376 31 61 81 77
2024/20257.651 344 953 637 1.345 2.815 1.557 0 0 0 0 0 0
Totale 21.768