DEI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 15.540
EU - Europa 10.609
AS - Asia 7.208
SA - Sud America 734
AF - Africa 204
OC - Oceania 121
Continente sconosciuto - Info sul continente non disponibili 3
Totale 34.419
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Nazione #
US - Stati Uniti d'America 15.345
RU - Federazione Russa 3.310
SG - Singapore 2.095
IT - Italia 2.007
CN - Cina 1.711
PL - Polonia 1.543
HK - Hong Kong 1.122
IE - Irlanda 929
SE - Svezia 824
VN - Vietnam 804
KR - Corea 625
BR - Brasile 589
DE - Germania 480
FI - Finlandia 373
FR - Francia 294
UA - Ucraina 282
IN - India 242
GB - Regno Unito 228
JP - Giappone 153
AU - Australia 119
CA - Canada 109
CH - Svizzera 87
TR - Turchia 79
BD - Bangladesh 62
NL - Olanda 60
MX - Messico 57
ES - Italia 54
JO - Giordania 54
AR - Argentina 50
ID - Indonesia 50
ZA - Sudafrica 46
IQ - Iraq 45
CI - Costa d'Avorio 43
BE - Belgio 36
CO - Colombia 27
NG - Nigeria 24
PK - Pakistan 22
RO - Romania 22
EC - Ecuador 18
VE - Venezuela 15
MA - Marocco 14
SA - Arabia Saudita 14
UZ - Uzbekistan 14
AT - Austria 13
SC - Seychelles 13
AZ - Azerbaigian 12
CL - Cile 12
PH - Filippine 12
PY - Paraguay 12
DZ - Algeria 11
LT - Lituania 11
BJ - Benin 10
KE - Kenya 10
TW - Taiwan 10
EG - Egitto 9
HU - Ungheria 9
TH - Thailandia 9
TN - Tunisia 9
KZ - Kazakistan 8
CZ - Repubblica Ceca 7
IL - Israele 7
MY - Malesia 7
NP - Nepal 7
PE - Perù 7
LB - Libano 6
OM - Oman 6
PT - Portogallo 6
CR - Costa Rica 5
DK - Danimarca 5
HR - Croazia 5
JM - Giamaica 5
KG - Kirghizistan 5
NI - Nicaragua 5
SN - Senegal 5
AE - Emirati Arabi Uniti 4
MO - Macao, regione amministrativa speciale della Cina 4
MU - Mauritius 4
AL - Albania 3
AM - Armenia 3
BG - Bulgaria 3
CY - Cipro 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
BH - Bahrain 2
BY - Bielorussia 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
EU - Europa 2
GD - Grenada 2
GE - Georgia 2
GR - Grecia 2
IR - Iran 2
LV - Lettonia 2
LY - Libia 2
MK - Macedonia 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SY - Repubblica araba siriana 2
UY - Uruguay 2
A1 - Anonimo 1
Totale 34.398
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Città #
Santa Clara 3.614
Ashburn 1.658
Warsaw 1.532
Singapore 1.508
Fairfield 1.038
Chandler 1.004
Hong Kong 933
Dublin 924
Seoul 595
Woodbridge 472
Cambridge 470
San Jose 464
Jacksonville 422
Houston 416
Seattle 414
Milan 406
Wilmington 360
Beijing 358
Hefei 338
The Dalles 263
Buffalo 251
Los Angeles 251
Ann Arbor 244
Munich 216
Princeton 213
Ho Chi Minh City 200
Florence 197
Dong Ket 192
Boston 185
Rome 174
Lauterbourg 171
Altamura 162
Hanoi 151
Tokyo 147
Council Bluffs 145
Mumbai 137
Lawrence 135
Dallas 131
Helsinki 128
Boardman 119
Moscow 114
Melbourne 113
New York 98
Shanghai 81
Kent 78
Bern 71
Medford 70
San Diego 63
Paris 60
São Paulo 51
Turku 49
Bologna 45
Phoenix 45
Guangzhou 44
Naples 44
Abidjan 43
Turin 43
Redondo Beach 41
Izmir 39
Clifton 38
Falls Church 37
Norwalk 37
Jakarta 36
Orem 36
Montreal 34
London 33
Chicago 32
Washington 32
Frankfurt am Main 31
Brussels 29
Da Nang 29
Hillsboro 29
Barcelona 28
Haiphong 28
Toronto 28
Figino 27
Lappeenranta 27
Verona 27
Johannesburg 26
Andover 23
Tianjin 23
Abuja 22
Bari 22
Chennai 22
Genoa 22
West Jordan 22
Brooklyn 21
Palermo 20
Philadelphia 20
San Francisco 20
Seongnam 20
Atlanta 19
Baghdad 19
Frankfurt Am Main 19
Denver 18
Mexico City 17
Miano 17
Stockholm 17
Venice 17
Dearborn 16
Totale 22.970
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Nome #
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 421
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 408
AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES 395
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) 324
Central muscarinic antinociception induced by ET-142 and SS-20 in rodents 312
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators 308
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 306
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 301
Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity 300
An easy one-step procedure for the synthesis of novel beta-functionalised tellurides 297
In vitro characterization of a novel, potent and selective M3 antagonist 283
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 277
N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR) 276
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 273
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 260
1,3-oxathiolane muscarinic ligands modified at the cationic head. 255
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli 253
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 250
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 245
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 244
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 236
Metformin reacts directly with glucose following the Maillard reaction pathway 233
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 232
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 230
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 226
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 224
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 220
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 214
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 213
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 212
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 211
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 211
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 211
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 211
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 208
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 207
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 207
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 205
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 203
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 203
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 202
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 202
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 201
S-(-)-ET126: a potent and selective M1 antagonist 200
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 197
Carbachol dimers as homobivalent modulators of muscarinic receptors 197
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 196
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 193
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 192
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 190
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 190
Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators 189
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 189
New phenylalkylamines as isoform selective HCN-Channels blockers 188
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 185
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 184
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM 183
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 182
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 182
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 181
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 181
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 181
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 181
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 180
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 178
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 178
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 178
Design of novel nicotinic ligands through 3D database searching 177
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 177
The medicinal chemistry of multidrug resistance (MDR) reversing drugs 177
P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells 177
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 176
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 176
Cholinergic Receptor Binding Profile of Hypericum perforatum L. and its Active Constituents 175
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 175
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 175
Isomers Recognition in HPLC-MS/MS Analysis of Human Plasma Samples by Using an Ion Trap Supported by a Linear Equations-Based Algorithm 172
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 172
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 172
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 171
Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina 171
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 170
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 170
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 169
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 169
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 168
Application of LEDA Algorithm for the characterization of Isomers in Simultaneous Degradation Study in Human Plasma by HPLC-MS/MS 166
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 165
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 163
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 163
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 163
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents 163
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 162
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 162
The piperazine scaffold for novel drug discovery efforts: the evidence to date 161
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF VERAPAMIL ANALOGS WITH RESTRICTED MOLECULAR FLEXIBILITY 161
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 160
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 160
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 159
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 158
Totale 20.940
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Categoria #
all - tutte 95.166
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 95.166
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.354 42 183 89 43 37 41 72 76 41 45 294 391
2022/20233.764 342 582 184 294 283 714 499 232 382 23 126 103
2023/20241.610 46 162 237 84 98 308 49 376 31 61 81 77
2024/20259.867 344 953 637 1.345 2.815 1.579 181 631 450 230 348 354
2025/202610.733 1.195 1.482 952 682 1.201 473 1.302 505 676 603 254 1.408
2026/20274 4 0 0 0 0 0 0 0 0 0 0 0
Totale 34.721