DEI, SILVIA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 14.112
EU - Europa 9.016
AS - Asia 5.771
SA - Sud America 672
AF - Africa 154
OC - Oceania 119
Continente sconosciuto - Info sul continente non disponibili 3
Totale 29.847
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 13.970
RU - Federazione Russa 3.307
SG - Singapore 1.728
PL - Polonia 1.541
CN - Cina 1.394
HK - Hong Kong 1.081
IE - Irlanda 928
SE - Svezia 820
IT - Italia 738
KR - Corea 622
BR - Brasile 557
DE - Germania 463
VN - Vietnam 367
FI - Finlandia 328
UA - Ucraina 281
IN - India 208
GB - Regno Unito 198
AU - Australia 118
FR - Francia 105
CH - Svizzera 86
CA - Canada 81
TR - Turchia 70
NL - Olanda 51
ID - Indonesia 50
JO - Giordania 50
ES - Italia 48
MX - Messico 44
AR - Argentina 43
CI - Costa d'Avorio 42
JP - Giappone 38
ZA - Sudafrica 36
BE - Belgio 35
BD - Bangladesh 28
IQ - Iraq 25
RO - Romania 18
CO - Colombia 17
PK - Pakistan 16
EC - Ecuador 15
MA - Marocco 13
SC - Seychelles 13
AT - Austria 12
VE - Venezuela 12
LT - Lituania 11
PY - Paraguay 11
BJ - Benin 10
CL - Cile 10
UZ - Uzbekistan 9
DZ - Algeria 8
HU - Ungheria 8
SA - Arabia Saudita 8
CZ - Repubblica Ceca 7
IL - Israele 7
KE - Kenya 7
KZ - Kazakistan 7
PH - Filippine 6
TN - Tunisia 6
TW - Taiwan 6
AZ - Azerbaigian 5
DK - Danimarca 5
EG - Egitto 5
HR - Croazia 5
PE - Perù 5
CR - Costa Rica 4
KG - Kirghizistan 4
LB - Libano 4
MO - Macao, regione amministrativa speciale della Cina 4
MU - Mauritius 4
NI - Nicaragua 4
NP - Nepal 4
OM - Oman 4
PT - Portogallo 4
SN - Senegal 4
TH - Thailandia 4
AE - Emirati Arabi Uniti 3
AM - Armenia 3
BG - Bulgaria 3
JM - Giamaica 3
MY - Malesia 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
CY - Cipro 2
EU - Europa 2
GE - Georgia 2
GR - Grecia 2
IR - Iran 2
LV - Lettonia 2
MK - Macedonia 2
NG - Nigeria 2
PS - Palestinian Territory 2
A1 - Anonimo 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BO - Bolivia 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GA - Gabon 1
GD - Grenada 1
GY - Guiana 1
Totale 29.837
Salva come PNG Salva come JPEG
Città #
Santa Clara 3.580
Warsaw 1.530
Ashburn 1.210
Singapore 1.159
Fairfield 1.038
Chandler 1.004
Dublin 924
Hong Kong 907
Seoul 595
Woodbridge 472
Cambridge 468
Jacksonville 421
Houston 415
Seattle 412
Wilmington 358
Beijing 341
Hefei 338
Buffalo 246
Ann Arbor 244
Los Angeles 223
Munich 216
Princeton 212
Dong Ket 192
Boston 184
Florence 171
Altamura 162
San Jose 148
The Dalles 139
Lawrence 135
Mumbai 134
Dallas 122
Melbourne 113
Moscow 113
Boardman 112
Helsinki 84
New York 84
Kent 78
Shanghai 73
Bern 71
Medford 70
Ho Chi Minh City 66
San Diego 59
Council Bluffs 58
Paris 58
Turku 49
São Paulo 47
Abidjan 42
Redondo Beach 41
Hanoi 40
Clifton 38
Izmir 38
Milan 38
Falls Church 37
Norwalk 37
Phoenix 37
Jakarta 36
Guangzhou 35
Tokyo 34
London 33
Montreal 33
Washington 31
Brussels 29
Barcelona 27
Toronto 27
Chicago 26
Lappeenranta 26
Hillsboro 24
Andover 23
Tianjin 22
West Jordan 22
Frankfurt am Main 20
Seongnam 20
Brooklyn 19
Frankfurt Am Main 19
Johannesburg 19
Philadelphia 19
Rome 19
Verona 18
Atlanta 17
Stockholm 17
Dearborn 16
Redwood City 16
Orem 15
Bengaluru 14
Chennai 14
San Francisco 14
Denver 13
Poplar 13
Pune 13
Rio de Janeiro 13
Yubileyny 13
Baghdad 12
Belo Horizonte 12
Brasília 12
Curitiba 11
Haiphong 11
Mexico City 11
Ankara 10
Cotonou 10
Groningen 10
Totale 20.051
Salva come PNG Salva come JPEG
Nome #
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 370
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 370
AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES 358
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) 301
Central muscarinic antinociception induced by ET-142 and SS-20 in rodents 289
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators 279
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 274
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 272
An easy one-step procedure for the synthesis of novel beta-functionalised tellurides 268
Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity 266
In vitro characterization of a novel, potent and selective M3 antagonist 261
N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR) 245
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 236
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 232
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 231
1,3-oxathiolane muscarinic ligands modified at the cationic head. 215
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 213
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 211
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli 211
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 209
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 209
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 205
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 201
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 200
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 196
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 194
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 190
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 190
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 189
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 188
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 187
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 187
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 187
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 186
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 186
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 185
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 184
S-(-)-ET126: a potent and selective M1 antagonist 183
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 179
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 179
Carbachol dimers as homobivalent modulators of muscarinic receptors 178
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 177
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 176
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 176
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 174
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 171
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 170
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 169
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 169
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 169
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 167
Metformin reacts directly with glucose following the Maillard reaction pathway 166
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 166
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 166
Design of novel nicotinic ligands through 3D database searching 166
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 166
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 164
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 163
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 162
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 162
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 162
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 161
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 161
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 160
P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells 160
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 159
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 158
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 157
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 157
Cholinergic Receptor Binding Profile of Hypericum perforatum L. and its Active Constituents 156
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 156
Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators 155
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 155
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 155
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents 155
New phenylalkylamines as isoform selective HCN-Channels blockers 153
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 153
Isomers Recognition in HPLC-MS/MS Analysis of Human Plasma Samples by Using an Ion Trap Supported by a Linear Equations-Based Algorithm 152
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 150
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 149
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 149
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 149
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 148
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 146
The medicinal chemistry of multidrug resistance (MDR) reversing drugs 146
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 145
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 144
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 144
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 144
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 143
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 143
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 143
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF VERAPAMIL ANALOGS WITH RESTRICTED MOLECULAR FLEXIBILITY 142
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 142
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM 142
Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina 141
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 141
Application of LEDA Algorithm for the characterization of Isomers in Simultaneous Degradation Study in Human Plasma by HPLC-MS/MS 140
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 139
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 138
Totale 18.486
Salva come PNG Salva come JPEG
Categoria #
all - tutte 83.920
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 83.920
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.102 0 0 0 0 0 0 64 176 160 301 106 295
2021/20221.354 42 183 89 43 37 41 72 76 41 45 294 391
2022/20233.764 342 582 184 294 283 714 499 232 382 23 126 103
2023/20241.610 46 162 237 84 98 308 49 376 31 61 81 77
2024/20259.867 344 953 637 1.345 2.815 1.579 181 631 450 230 348 354
2025/20266.165 1.195 1.482 952 682 1.201 473 180 0 0 0 0 0
Totale 30.149