DEI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 7.933
EU - Europa 5.999
AS - Asia 1.576
AF - Africa 21
SA - Sud America 6
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 1
Totale 15.539
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Nazione #
US - Stati Uniti d'America 7.910
PL - Polonia 1.515
RU - Federazione Russa 1.014
IE - Irlanda 926
SE - Svezia 805
IT - Italia 663
HK - Hong Kong 468
CN - Cina 316
SG - Singapore 306
UA - Ucraina 270
DE - Germania 220
FI - Finlandia 211
VN - Vietnam 198
IN - India 148
GB - Regno Unito 135
CH - Svizzera 83
JO - Giordania 44
TR - Turchia 44
KR - Corea 35
FR - Francia 33
BE - Belgio 30
ES - Italia 29
NL - Olanda 25
CA - Canada 23
RO - Romania 17
SC - Seychelles 13
HR - Croazia 5
JP - Giappone 5
AT - Austria 4
DZ - Algeria 4
MO - Macao, regione amministrativa speciale della Cina 4
MU - Mauritius 4
CZ - Repubblica Ceca 3
HU - Ungheria 3
AR - Argentina 2
EU - Europa 2
MK - Macedonia 2
TW - Taiwan 2
A1 - Anonimo 1
BG - Bulgaria 1
CL - Cile 1
CO - Colombia 1
EC - Ecuador 1
GR - Grecia 1
IL - Israele 1
IR - Iran 1
KZ - Kazakistan 1
LB - Libano 1
LU - Lussemburgo 1
LV - Lettonia 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PE - Perù 1
PH - Filippine 1
RS - Serbia 1
UZ - Uzbekistan 1
Totale 15.539
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Città #
Warsaw 1.510
Fairfield 1.038
Chandler 1.004
Dublin 922
Ashburn 655
Woodbridge 472
Cambridge 468
Jacksonville 419
Seattle 409
Houston 405
Wilmington 356
Hong Kong 295
Ann Arbor 244
Singapore 220
Princeton 212
Dong Ket 192
Boston 173
Altamura 162
Florence 150
Lawrence 135
Mumbai 127
Boardman 110
Beijing 109
Buffalo 102
Bern 71
Medford 70
Shanghai 67
San Diego 59
Kent 43
Santa Clara 40
Izmir 38
Falls Church 37
Norwalk 37
New York 35
Los Angeles 30
Helsinki 29
Washington 29
Brussels 28
Barcelona 27
Moscow 27
Guangzhou 26
Milan 26
Hillsboro 24
Andover 23
West Jordan 22
Phoenix 21
Seongnam 20
Frankfurt Am Main 19
Lappeenranta 19
Philadelphia 19
Verona 18
Dearborn 16
Redwood City 16
Rome 16
Toronto 15
Pune 13
London 11
Seoul 11
Gavirate 9
Düsseldorf 8
Auburn Hills 7
Treviglio 7
Groningen 6
Laurel 6
Ottawa 6
Tappahannock 6
Frankfurt am Main 5
Misano Adriatico 5
Munich 5
Siena 5
Genoa 4
Grafing 4
Hanover 4
Macao 4
Menlo Park 4
Nanjing 4
Nuremberg 4
Sesto Fiorentino 4
Amherst 3
Amsterdam 3
Bologna 3
Budapest 3
Cedar Knolls 3
Edinburgh 3
Iclod 3
Leawood 3
Redmond 3
Reggio Emilia 3
San Martino Buon Albergo 3
Sassano 3
Scandicci 3
Tokyo 3
Trumbull 3
Vienna 3
Wroclaw 3
Zurich 3
Acton 2
Arezzo 2
Ascoli Piceno 2
Buenos Aires 2
Totale 11.060
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Nome #
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 286
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 263
AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES 260
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) 238
Central muscarinic antinociception induced by ET-142 and SS-20 in rodents 231
In vitro characterization of a novel, potent and selective M3 antagonist 222
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 219
Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity 208
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 206
An easy one-step procedure for the synthesis of novel beta-functionalised tellurides 197
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 152
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 149
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 144
N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR) 137
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 135
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 124
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 123
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli 122
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 120
1,3-oxathiolane muscarinic ligands modified at the cationic head. 120
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 120
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 119
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 119
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 119
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 119
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 116
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 116
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 115
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 114
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 111
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 111
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 110
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 109
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 108
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 107
The medicinal chemistry of multidrug resistance (MDR) reversing drugs 107
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 106
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 105
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 105
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 104
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 103
Carbachol dimers as homobivalent modulators of muscarinic receptors 102
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 101
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 100
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 100
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 99
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 99
Design of novel nicotinic ligands through 3D database searching 98
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 98
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 97
S-(-)-ET126: a potent and selective M1 antagonist 97
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 97
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 97
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 96
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 96
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 95
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 95
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 95
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 94
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 94
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 94
Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone 93
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 92
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 92
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 91
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 89
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 89
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 88
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 87
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 87
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 86
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 86
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 85
Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain 84
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 84
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 82
New quinoline derivatives as nicotinic receptor modulators 82
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 82
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 82
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 81
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 81
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 80
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 80
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists 80
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 80
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 80
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 79
Reversal of multidrug resistance by verapamil analogues 79
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents 79
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF VERAPAMIL ANALOGS WITH RESTRICTED MOLECULAR FLEXIBILITY 78
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 78
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 77
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 76
Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity 76
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 76
New phenylalkylamines as isoform selective HCN-Channels blockers 74
SYNTHESIS AND CARDIOVASCULAR PROPERTIES OF FLUORENYL DERIVATIVES RELATED TO VERAPAMIL 73
Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina 73
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 72
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM 71
Totale 11.127
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Categoria #
all - tutte 50.328
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.328
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.137 0 0 84 231 276 301 252 316 232 161 241 43
2020/20212.042 167 127 120 219 52 255 64 176 160 301 106 295
2021/20221.354 42 183 89 43 37 41 72 76 41 45 294 391
2022/20233.764 342 582 184 294 283 714 499 232 382 23 126 103
2023/20241.610 46 162 237 84 98 308 49 376 31 61 81 77
2024/20251.713 344 953 416 0 0 0 0 0 0 0 0 0
Totale 15.830