DEI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 15.097
EU - Europa 9.383
AS - Asia 7.150
SA - Sud America 727
AF - Africa 200
OC - Oceania 121
Continente sconosciuto - Info sul continente non disponibili 3
Totale 32.681
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Nazione #
US - Stati Uniti d'America 14.927
RU - Federazione Russa 3.310
SG - Singapore 2.083
CN - Cina 1.693
PL - Polonia 1.543
HK - Hong Kong 1.117
IE - Irlanda 929
SE - Svezia 822
VN - Vietnam 804
IT - Italia 789
KR - Corea 625
BR - Brasile 587
DE - Germania 480
FI - Finlandia 373
FR - Francia 294
UA - Ucraina 282
IN - India 241
GB - Regno Unito 228
JP - Giappone 153
AU - Australia 119
CA - Canada 94
CH - Svizzera 87
TR - Turchia 78
NL - Olanda 57
ES - Italia 54
JO - Giordania 54
MX - Messico 53
ID - Indonesia 50
AR - Argentina 49
ZA - Sudafrica 45
BD - Bangladesh 44
IQ - Iraq 44
CI - Costa d'Avorio 43
BE - Belgio 36
CO - Colombia 24
NG - Nigeria 24
PK - Pakistan 22
RO - Romania 22
EC - Ecuador 18
VE - Venezuela 15
MA - Marocco 14
SA - Arabia Saudita 14
UZ - Uzbekistan 14
AT - Austria 13
SC - Seychelles 13
AZ - Azerbaigian 12
CL - Cile 12
PH - Filippine 12
PY - Paraguay 12
LT - Lituania 11
BJ - Benin 10
DZ - Algeria 10
KE - Kenya 10
TW - Taiwan 10
TH - Thailandia 9
TN - Tunisia 9
EG - Egitto 8
HU - Ungheria 8
KZ - Kazakistan 8
CZ - Repubblica Ceca 7
IL - Israele 7
NP - Nepal 7
LB - Libano 6
MY - Malesia 6
OM - Oman 6
PE - Perù 6
DK - Danimarca 5
HR - Croazia 5
KG - Kirghizistan 5
PT - Portogallo 5
SN - Senegal 5
AE - Emirati Arabi Uniti 4
CR - Costa Rica 4
MO - Macao, regione amministrativa speciale della Cina 4
MU - Mauritius 4
NI - Nicaragua 4
AL - Albania 3
AM - Armenia 3
BG - Bulgaria 3
JM - Giamaica 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
BH - Bahrain 2
CY - Cipro 2
ET - Etiopia 2
EU - Europa 2
GE - Georgia 2
GR - Grecia 2
IR - Iran 2
LV - Lettonia 2
MK - Macedonia 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SY - Repubblica araba siriana 2
UY - Uruguay 2
A1 - Anonimo 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BO - Bolivia 1
Totale 32.660
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Città #
Santa Clara 3.595
Ashburn 1.553
Warsaw 1.532
Singapore 1.498
Fairfield 1.038
Chandler 1.004
Hong Kong 928
Dublin 924
Seoul 595
Woodbridge 472
Cambridge 470
Jacksonville 422
Houston 416
Seattle 413
San Jose 375
Wilmington 358
Beijing 348
Hefei 338
The Dalles 263
Buffalo 249
Ann Arbor 244
Los Angeles 234
Munich 216
Princeton 212
Ho Chi Minh City 200
Dong Ket 192
Boston 184
Florence 173
Lauterbourg 171
Altamura 162
Hanoi 151
Tokyo 147
Council Bluffs 144
Mumbai 137
Lawrence 135
Helsinki 128
Dallas 127
Moscow 114
Boardman 113
Melbourne 113
New York 89
Shanghai 80
Kent 78
Bern 71
Medford 70
San Diego 61
Paris 60
São Paulo 50
Turku 49
Guangzhou 44
Milan 44
Abidjan 43
Phoenix 42
Redondo Beach 41
Izmir 39
Clifton 38
Falls Church 37
Norwalk 37
Jakarta 36
Orem 35
Montreal 34
London 33
Frankfurt am Main 31
Washington 31
Brussels 29
Da Nang 29
Barcelona 28
Haiphong 28
Lappeenranta 27
Rome 27
Toronto 27
Chicago 26
Hillsboro 26
Johannesburg 26
Andover 23
Tianjin 23
Abuja 22
Chennai 22
West Jordan 22
Seongnam 20
Brooklyn 19
Frankfurt Am Main 19
Philadelphia 19
Atlanta 18
Baghdad 18
San Francisco 18
Verona 18
Stockholm 17
Dearborn 16
Redwood City 16
Bengaluru 15
Denver 15
Mexico City 14
Rio de Janeiro 14
Shenzhen 14
Poplar 13
Pune 13
Yubileyny 13
Belo Horizonte 12
Brasília 12
Totale 21.979
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Nome #
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 403
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 395
AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES 384
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) 317
Central muscarinic antinociception induced by ET-142 and SS-20 in rodents 301
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators 297
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 293
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 292
Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity 287
In vitro characterization of a novel, potent and selective M3 antagonist 279
An easy one-step procedure for the synthesis of novel beta-functionalised tellurides 278
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 270
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 265
N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR) 263
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 249
1,3-oxathiolane muscarinic ligands modified at the cationic head. 240
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 231
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 231
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 231
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 226
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli 224
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 223
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 220
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 216
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 208
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 206
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 205
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 205
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 205
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 203
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 203
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 203
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 202
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 201
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 201
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 200
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 198
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 198
Metformin reacts directly with glucose following the Maillard reaction pathway 197
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 196
S-(-)-ET126: a potent and selective M1 antagonist 196
Carbachol dimers as homobivalent modulators of muscarinic receptors 195
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 192
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 192
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 191
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 189
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 188
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 183
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 182
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 182
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 181
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 181
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 179
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 177
New phenylalkylamines as isoform selective HCN-Channels blockers 177
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 177
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 176
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM 176
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 175
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 175
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 175
Design of novel nicotinic ligands through 3D database searching 174
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 174
Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators 173
Cholinergic Receptor Binding Profile of Hypericum perforatum L. and its Active Constituents 173
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 173
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 173
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 172
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 172
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 172
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 172
Isomers Recognition in HPLC-MS/MS Analysis of Human Plasma Samples by Using an Ion Trap Supported by a Linear Equations-Based Algorithm 171
P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells 171
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 168
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 165
The medicinal chemistry of multidrug resistance (MDR) reversing drugs 165
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 165
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 164
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 163
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 163
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 163
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 163
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 161
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 161
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents 161
Application of LEDA Algorithm for the characterization of Isomers in Simultaneous Degradation Study in Human Plasma by HPLC-MS/MS 160
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 160
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF VERAPAMIL ANALOGS WITH RESTRICTED MOLECULAR FLEXIBILITY 159
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 159
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 158
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 157
Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina 157
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 157
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 157
The piperazine scaffold for novel drug discovery efforts: the evidence to date 156
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 155
Alpha-tropanyl esters that increase central ACh release: enantioselectivity studies support a double mechanism of action. 154
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 152
Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain 151
Simultaneous Degradation Study of Isomers in Human Plasma by HPLC-MS/MS and Application of LEDA Algorithm for Their Characterization 150
Totale 20.059
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Categoria #
all - tutte 89.330
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 89.330
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021702 0 0 0 0 0 0 0 0 0 301 106 295
2021/20221.354 42 183 89 43 37 41 72 76 41 45 294 391
2022/20233.764 342 582 184 294 283 714 499 232 382 23 126 103
2023/20241.610 46 162 237 84 98 308 49 376 31 61 81 77
2024/20259.867 344 953 637 1.345 2.815 1.579 181 631 450 230 348 354
2025/20268.999 1.195 1.482 952 682 1.201 473 1.302 505 676 531 0 0
Totale 32.983