DEI, SILVIA
 Distribuzione geografica
Continente #
NA - Nord America 12.046
EU - Europa 7.777
AS - Asia 2.684
SA - Sud America 156
OC - Oceania 114
AF - Africa 81
Continente sconosciuto - Info sul continente non disponibili 3
Totale 22.861
Nazione #
US - Stati Uniti d'America 12.007
RU - Federazione Russa 2.437
PL - Polonia 1.517
HK - Hong Kong 971
IE - Irlanda 927
SE - Svezia 806
SG - Singapore 770
IT - Italia 702
CN - Cina 382
DE - Germania 360
UA - Ucraina 273
FI - Finlandia 271
VN - Vietnam 198
IN - India 149
GB - Regno Unito 140
BR - Brasile 137
AU - Australia 113
FR - Francia 91
CH - Svizzera 85
TR - Turchia 51
JO - Giordania 45
CI - Costa d'Avorio 42
NL - Olanda 39
ID - Indonesia 35
KR - Corea 35
BE - Belgio 32
CA - Canada 31
ES - Italia 30
RO - Romania 17
SC - Seychelles 13
AR - Argentina 8
HU - Ungheria 8
JP - Giappone 8
AT - Austria 7
MX - Messico 7
DZ - Algeria 6
DK - Danimarca 5
HR - Croazia 5
IQ - Iraq 4
LT - Lituania 4
MA - Marocco 4
MO - Macao, regione amministrativa speciale della Cina 4
MU - Mauritius 4
PT - Portogallo 4
ZA - Sudafrica 4
CZ - Repubblica Ceca 3
EG - Egitto 3
IL - Israele 3
KG - Kirghizistan 3
PY - Paraguay 3
TW - Taiwan 3
UZ - Uzbekistan 3
AM - Armenia 2
CO - Colombia 2
CY - Cipro 2
EC - Ecuador 2
EU - Europa 2
GE - Georgia 2
GR - Grecia 2
KZ - Kazakistan 2
LV - Lettonia 2
MK - Macedonia 2
NG - Nigeria 2
OM - Oman 2
PK - Pakistan 2
SK - Slovacchia (Repubblica Slovacca) 2
A1 - Anonimo 1
AO - Angola 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BO - Bolivia 1
CL - Cile 1
EE - Estonia 1
IR - Iran 1
JM - Giamaica 1
KE - Kenya 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
LK - Sri Lanka 1
LU - Lussemburgo 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PE - Perù 1
PH - Filippine 1
PS - Palestinian Territory 1
RS - Serbia 1
SN - Senegal 1
TH - Thailandia 1
VE - Venezuela 1
Totale 22.861
Città #
Santa Clara 3.553
Warsaw 1.511
Fairfield 1.038
Chandler 1.004
Dublin 923
Hong Kong 798
Ashburn 684
Woodbridge 472
Cambridge 468
Jacksonville 419
Seattle 409
Houston 405
Singapore 399
Wilmington 356
Ann Arbor 244
Princeton 212
Dong Ket 192
Boston 173
Florence 163
Altamura 162
Lawrence 135
Munich 129
Mumbai 127
Beijing 114
Melbourne 113
Boardman 110
Buffalo 102
Helsinki 81
Bern 71
Shanghai 71
Medford 70
Moscow 68
San Diego 59
Paris 57
Los Angeles 45
Kent 43
Abidjan 42
Izmir 38
Falls Church 37
Norwalk 37
Jakarta 35
New York 35
Milan 30
Brussels 29
Washington 29
Guangzhou 28
Barcelona 27
Hillsboro 24
Andover 23
West Jordan 22
Lappeenranta 21
Phoenix 21
Seongnam 20
Frankfurt Am Main 19
Philadelphia 19
Verona 18
Rome 17
Toronto 17
Dearborn 16
Redwood City 16
Pune 13
Yubileyny 13
London 12
Seoul 11
Ottawa 10
Frankfurt am Main 9
Gavirate 9
Düsseldorf 8
São Paulo 8
The Dalles 8
Auburn Hills 7
Treviglio 7
Amsterdam 6
Groningen 6
Laurel 6
Nuremberg 6
Romola 6
Tappahannock 6
Misano Adriatico 5
Siena 5
Tokyo 5
Zurich 5
Baghdad 4
Genoa 4
Grafing 4
Hanover 4
Macao 4
Menlo Park 4
Nanjing 4
Parma 4
Rio de Janeiro 4
Sesto Fiorentino 4
Vienna 4
Amherst 3
Bishkek 3
Boksburg 3
Bologna 3
Brasília 3
Budapest 3
Buenos Aires 3
Totale 15.836
Nome #
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 322
AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES 301
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 299
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) 277
Central muscarinic antinociception induced by ET-142 and SS-20 in rodents 257
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 250
In vitro characterization of a novel, potent and selective M3 antagonist 244
Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity 240
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators 238
An easy one-step procedure for the synthesis of novel beta-functionalised tellurides 237
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 236
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 192
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 186
N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR) 178
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 177
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 172
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 168
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 166
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 162
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 159
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 156
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli 156
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 154
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 153
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 153
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 151
1,3-oxathiolane muscarinic ligands modified at the cationic head. 151
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 148
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 148
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 148
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 148
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 148
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 148
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 146
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 145
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 143
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 142
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 141
Carbachol dimers as homobivalent modulators of muscarinic receptors 141
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 140
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 138
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 137
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 135
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 134
Design of novel nicotinic ligands through 3D database searching 133
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 132
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 132
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 132
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 131
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 130
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 130
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 129
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 129
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 128
The medicinal chemistry of multidrug resistance (MDR) reversing drugs 128
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 128
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 128
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 127
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 126
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 124
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 124
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 124
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 123
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 123
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 122
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 122
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents 122
S-(-)-ET126: a potent and selective M1 antagonist 121
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 120
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 120
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 120
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 119
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 119
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 118
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 118
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 117
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 117
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 116
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 116
New phenylalkylamines as isoform selective HCN-Channels blockers 116
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 115
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 115
Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone 115
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM 115
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 115
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 114
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 113
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 113
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 112
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 112
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 112
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 112
Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain 112
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 112
New quinoline derivatives as nicotinic receptor modulators 111
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 111
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 111
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 110
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 108
Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina 108
Totale 14.675
Categoria #
all - tutte 66.445
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 66.445


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020445 0 0 0 0 0 0 0 0 0 161 241 43
2020/20212.042 167 127 120 219 52 255 64 176 160 301 106 295
2021/20221.354 42 183 89 43 37 41 72 76 41 45 294 391
2022/20233.764 342 582 184 294 283 714 499 232 382 23 126 103
2023/20241.610 46 162 237 84 98 308 49 376 31 61 81 77
2024/20259.045 344 953 637 1.345 2.815 1.579 181 631 450 110 0 0
Totale 23.162