A general approach for the synthesis of carbonic anhydrases glycoinhibitors belonging to an aminoxysulfonamide series is presented using a Ferrier sulfonamidoglycosylation reaction on glycals. All the compounds showed good in vitro inhibitory activity against four human carbonic anhydrase isoforms, with selectivity against the cytosolic (hCA II) vs the tumor associated (hCA IX and XII) enzymes.
Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series / Ombouma, Joanna; Vullo, Daniela; Dumy, Pascal; Supuran, Claudiu T.; Winum, Jean-Yves. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - STAMPA. - 6:(2015), pp. 819-821. [10.1021/acsmedchemlett.5b00175]
Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series
VULLO, DANIELA;SUPURAN, CLAUDIU TRANDAFIR;
2015
Abstract
A general approach for the synthesis of carbonic anhydrases glycoinhibitors belonging to an aminoxysulfonamide series is presented using a Ferrier sulfonamidoglycosylation reaction on glycals. All the compounds showed good in vitro inhibitory activity against four human carbonic anhydrase isoforms, with selectivity against the cytosolic (hCA II) vs the tumor associated (hCA IX and XII) enzymes.
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