A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site.
Out of the active site binding pocket for carbonic anhydrase inhibitors / D'Ambrosio, Katia; Carradori, Simone; Monti, Simona M; Buonanno, Martina; Secci, Daniela; Vullo, Daniela; Supuran, Claudiu T; De Simone, Giuseppina. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - STAMPA. - 51:(2015), pp. 302-305. [10.1039/c4cc07320g]
Out of the active site binding pocket for carbonic anhydrase inhibitors
VULLO, DANIELA;SUPURAN, CLAUDIU TRANDAFIR;
2015
Abstract
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site.
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