AIM: The aim of this study was to identify a subgroup of breast cancer patients in whom it is possible to avoid axillary lymph node dissection (ALND) when the sentinel lymph node (SLN) is positive. METHODS: A series of 292 patients treated with breast-conserving surgery or mastectomy underwent ALND after positive SLN detection. To correlate SLN metastasis with the chances of finding additional metastasis in non-SLNs we evaluated the main clinicopathological characteristics. No patients received adjuvant radiotherapy to the axillary region. RESULTS: Fifty-six patients (35.4%) with positive SLNs for macrometastases (n = 158) had additional metastases upon completion ALND compared with 7 patients (5.2%) with micrometastases in the SLN (n = 132). Cases with a higher number of positive axillary lymph nodes tended to have higher pT stage (p = 0.004). In multivariate analysis, pT was confirmed as an independent predictor of non-SLN metastases (OR = 2.40; 95% CI = 1.16-4.99). No patients with micrometastases in SLN and cancer lt;10 mm had additional positive non-SLNs. CONCLUSIONS: Our results, in agreement with the major published studies, suggest that ALND can be avoided in selected patients without the need for additional treatment to the axillary region.

Predictive factors for additional non-sentinel lymph node involvement in breast cancer patients with one positive sentinel node / Meattini, Icro; Saieva, Calogero; Bertocci, Silvia; Francolini, Giulio; Zei, Giacomo; De Luca Cardillo, Carla; Scotti, Vieri; Greto, Daniela; Bonomo, Pierluigi; Orzalesi, Lorenzo; Bianchi, Simonetta; Livi, Lorenzo. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 101:(2015), pp. 78-83. [10.5301/tj.5000220]

Predictive factors for additional non-sentinel lymph node involvement in breast cancer patients with one positive sentinel node

MEATTINI, ICRO;BERTOCCI, SILVIA;FRANCOLINI, GIULIO;ZEI, GIACOMO;DE LUCA CARDILLO, CARLA;SCOTTI, VIERI;GRETO, DANIELA;BONOMO, PIERLUIGI;ORZALESI, LORENZO;BIANCHI, SIMONETTA;LIVI, LORENZO
2015

Abstract

AIM: The aim of this study was to identify a subgroup of breast cancer patients in whom it is possible to avoid axillary lymph node dissection (ALND) when the sentinel lymph node (SLN) is positive. METHODS: A series of 292 patients treated with breast-conserving surgery or mastectomy underwent ALND after positive SLN detection. To correlate SLN metastasis with the chances of finding additional metastasis in non-SLNs we evaluated the main clinicopathological characteristics. No patients received adjuvant radiotherapy to the axillary region. RESULTS: Fifty-six patients (35.4%) with positive SLNs for macrometastases (n = 158) had additional metastases upon completion ALND compared with 7 patients (5.2%) with micrometastases in the SLN (n = 132). Cases with a higher number of positive axillary lymph nodes tended to have higher pT stage (p = 0.004). In multivariate analysis, pT was confirmed as an independent predictor of non-SLN metastases (OR = 2.40; 95% CI = 1.16-4.99). No patients with micrometastases in SLN and cancer lt;10 mm had additional positive non-SLNs. CONCLUSIONS: Our results, in agreement with the major published studies, suggest that ALND can be avoided in selected patients without the need for additional treatment to the axillary region.
2015
101
78
83
Meattini, Icro; Saieva, Calogero; Bertocci, Silvia; Francolini, Giulio; Zei, Giacomo; De Luca Cardillo, Carla; Scotti, Vieri; Greto, Daniela; Bonomo, ...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1017919
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