The aim of the present work was that of study two strategies to overcome Cisplatin chemoresistance in colorectal cancer: (1) to exploit K+ ion channels modulating agents as new therapeutic tools in order to increase Cisplatin therapeutic potential in colorectal cancer cells (2) to test two new Cisplatin-analogues, cis-Pt-I2 and cis-Pt-Br2, with increased selectivity in order to overcome resistance in a panel of tumor cell lines.
Novel strategies to overcome Cisplatin resistance in colorectal cancer / Bartoli, Gianluca. - (2016).
Novel strategies to overcome Cisplatin resistance in colorectal cancer.
BARTOLI, GIANLUCA
2016
Abstract
The aim of the present work was that of study two strategies to overcome Cisplatin chemoresistance in colorectal cancer: (1) to exploit K+ ion channels modulating agents as new therapeutic tools in order to increase Cisplatin therapeutic potential in colorectal cancer cells (2) to test two new Cisplatin-analogues, cis-Pt-I2 and cis-Pt-Br2, with increased selectivity in order to overcome resistance in a panel of tumor cell lines.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
PhD Thesis Dr. Gianluca Bartoli.pdf
accesso aperto
Descrizione: Tesi di dottorato Dr. Gianluca Bartoli
Tipologia:
Tesi di dottorato
Licenza:
Creative commons
Dimensione
4.15 MB
Formato
Adobe PDF
|
4.15 MB | Adobe PDF |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
