Abstract Parathyroid hormone (PTH) and the polyhormone parathyroid hormone-related peptide (PTHrP) play key roles in organs not classically related to the maintenance of bone and mineral metabolism. Indeed, they exert their actions through binding the PTH/PTHrP receptor, namely, PTH1R, which is expressed in several tissues other than kidney and bone. While PTH acts as a real hormone and displays endocrine actions, PTHrP acts mainly as a paracrine/autocrine factor, regulating cell proliferation and specific functions, both in development and physiopathology. Circulating PTH has been shown to mobilize hematopoietic stem cells both in vitro and in vivo, in animals and humans, and shows promising regenerative properties in damaged tissues after ischemia/reperfusion. Specific forms of PTHrP retained within the cell play key roles in the control of cell cycle and could be addressed to control abnormal proliferation in diseases such as cancer or the initial stages of atherosclerosis. Totally unexpected properties in sustaining innate immunity have recently been demonstrated for PTH, which in concert with 1,25(OH)2 vitamin D elicit the production of antimicrobial antigens in response to pathogens in the skin barrier. Translational studies are needed in order to confirm the importance of these mechanisms in humans and to assess whether the intermittent administration of PTH could elicit specific actions in vivo.

PTH and PTHrP: Nonclassical targets / Cianferotti, Luisella. - ELETTRONICO. - (2015), pp. 111-126. [10.1007/978-88-470-5376-2_12]

PTH and PTHrP: Nonclassical targets

CIANFEROTTI, LUISELLA
2015

Abstract

Abstract Parathyroid hormone (PTH) and the polyhormone parathyroid hormone-related peptide (PTHrP) play key roles in organs not classically related to the maintenance of bone and mineral metabolism. Indeed, they exert their actions through binding the PTH/PTHrP receptor, namely, PTH1R, which is expressed in several tissues other than kidney and bone. While PTH acts as a real hormone and displays endocrine actions, PTHrP acts mainly as a paracrine/autocrine factor, regulating cell proliferation and specific functions, both in development and physiopathology. Circulating PTH has been shown to mobilize hematopoietic stem cells both in vitro and in vivo, in animals and humans, and shows promising regenerative properties in damaged tissues after ischemia/reperfusion. Specific forms of PTHrP retained within the cell play key roles in the control of cell cycle and could be addressed to control abnormal proliferation in diseases such as cancer or the initial stages of atherosclerosis. Totally unexpected properties in sustaining innate immunity have recently been demonstrated for PTH, which in concert with 1,25(OH)2 vitamin D elicit the production of antimicrobial antigens in response to pathogens in the skin barrier. Translational studies are needed in order to confirm the importance of these mechanisms in humans and to assess whether the intermittent administration of PTH could elicit specific actions in vivo.
2015
9788847053762
9788847053762
Hypoparathyroidism
111
126
Cianferotti, Luisella
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1065976
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