Identification of New Psychoactive Substances (NPS) in biological and non-biological samples represents a hard challenge for forensic toxicologists. Their great chemical variety and the speed with which new NPS are synthesized and spread, make stringent the need of advanced tools for their detection based on multidisciplinary approaches. For this reason, in august 2016, the “Unit of Research and Innovation in Forensic Toxicology and Neuroscience of Addiction” (U.R.I.To.N.) was founded by the Forensic Toxicology Division of the University of Florence. In this Research Unit, various professionals (i.e. forensic toxicologists, chemists, physicians) collaborate to study all the aspects of drugs of abuse, especially NPS. Herein we describe the multidisciplinary approach comprising liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), gas chromatography hyphenated to mass spectrometry (GC-MS) and solution nuclear magnetic resonance (NMR) analysis that allowed the identification of three NPS such as 1-(benzofuran-5-yl)-N-methylpropan-2-amine (5-MAPB), 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethan-1-one (bk-2C-B) and 3-(2-aminopropyl)indole (α-methyltryptamine, AMT) in seized materials.

Advances in New Psychoactive Substances Identification: The U.R.I.To.N Consortium / Bertol, Elisabetta; Vaiano, Fabio; Mari, Francesco; Di Milia, Maria Grazia; Bua, Silvia; Supuran, Claudiu Trandafir; Carta, Fabrizio. - In: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. - ISSN 1475-6366. - STAMPA. - 32:(2017), pp. 841-849. [10.1080/14756366.2017.1333987]

Advances in New Psychoactive Substances Identification: The U.R.I.To.N Consortium

BERTOL, ELISABETTA;VAIANO, FABIO;DI MILIA, MARIA GRAZIA;BUA, SILVIA;SUPURAN, CLAUDIU TRANDAFIR;CARTA, FABRIZIO
2017

Abstract

Identification of New Psychoactive Substances (NPS) in biological and non-biological samples represents a hard challenge for forensic toxicologists. Their great chemical variety and the speed with which new NPS are synthesized and spread, make stringent the need of advanced tools for their detection based on multidisciplinary approaches. For this reason, in august 2016, the “Unit of Research and Innovation in Forensic Toxicology and Neuroscience of Addiction” (U.R.I.To.N.) was founded by the Forensic Toxicology Division of the University of Florence. In this Research Unit, various professionals (i.e. forensic toxicologists, chemists, physicians) collaborate to study all the aspects of drugs of abuse, especially NPS. Herein we describe the multidisciplinary approach comprising liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), gas chromatography hyphenated to mass spectrometry (GC-MS) and solution nuclear magnetic resonance (NMR) analysis that allowed the identification of three NPS such as 1-(benzofuran-5-yl)-N-methylpropan-2-amine (5-MAPB), 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethan-1-one (bk-2C-B) and 3-(2-aminopropyl)indole (α-methyltryptamine, AMT) in seized materials.
2017
32
841
849
Bertol, Elisabetta; Vaiano, Fabio; Mari, Francesco; Di Milia, Maria Grazia; Bua, Silvia; Supuran, Claudiu Trandafir; Carta, Fabrizio
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1086540
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