Treatment of premature ejaculation and comorbid endocrine and metabolic disorders

Recent evidence has pointed out the possibility that gonadal, thyroid and pituitary hormones (oxytocin and prolactin) might be involved in the control of the ejaculatory process and its overall latency time, along with all other aspects of the male reproduction system. Restoring euthyroidism, in hyperthyroidism-associated premature ejaculation can improve ejaculatory latency, although a limited number of subjects has been evaluated so far. Hypogonadism and hypothyroidism might be associated with delayed ejaculation and in the latter case, improvement of intravaginal ejaculation latency time has been reported only after correcting the hypothyroidism. Larger and longer studies are advisable in order to better clarify these points.