The lipid sensor oleoylethanolamide (OEA), an endogenous high-a nity agonist of peroxisome proliferator-activated receptor-α (PPAR-α) secreted in the proximal intestine, is endowed with several distinctive homeostatic properties, such as control of appetite, anti-in ammatory activity, stimulation of lipolysis and fatty acid oxidation. When administered exogenously, OEA has bene cial e ects in several cognitive paradigms; therefore, in all respects, OEA can be considered a hormone of the gut- brain axis. Here we report an unexplored modulatory e ect of OEA on the intestinal microbiota and on immune response. Our study shows for the rst time that sub-chronic OEA administration to mice fed a normal chow pellet diet, changes the faecal microbiota pro le, shifting the Firmicutes:Bacteroidetes ratio in favour of Bacteroidetes (in particular Bacteroides genus) and decreasing Firmicutes (Lactobacillus), and reduces intestinal cytokines expression by immune cells isolated from Peyer’s patches. Our results suggest that sub-chronic OEA treatment modulates gut microbiota composition towards a “lean-like phenotype”, and polarises gut-speci c immune responses mimicking the e ect of a diet low in fat and high in polysaccharides content.

Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s Patches of mice / Monica Di Paola, Elena Bonechi, Gustavo Provensi, Alessia Costa, Gerard Clarke, Clara Ballerini, Carlotta De Filippo , M. Beatrice Passani. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - ELETTRONICO. - 8:(2018), pp. 1-12. [10.1038/s41598-018-32925-x]

Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s Patches of mice

Monica Di Paola;Elena Bonechi;Gustavo Provensi;Alessia Costa;Clara Ballerini;M. Beatrice Passani
2018

Abstract

The lipid sensor oleoylethanolamide (OEA), an endogenous high-a nity agonist of peroxisome proliferator-activated receptor-α (PPAR-α) secreted in the proximal intestine, is endowed with several distinctive homeostatic properties, such as control of appetite, anti-in ammatory activity, stimulation of lipolysis and fatty acid oxidation. When administered exogenously, OEA has bene cial e ects in several cognitive paradigms; therefore, in all respects, OEA can be considered a hormone of the gut- brain axis. Here we report an unexplored modulatory e ect of OEA on the intestinal microbiota and on immune response. Our study shows for the rst time that sub-chronic OEA administration to mice fed a normal chow pellet diet, changes the faecal microbiota pro le, shifting the Firmicutes:Bacteroidetes ratio in favour of Bacteroidetes (in particular Bacteroides genus) and decreasing Firmicutes (Lactobacillus), and reduces intestinal cytokines expression by immune cells isolated from Peyer’s patches. Our results suggest that sub-chronic OEA treatment modulates gut microbiota composition towards a “lean-like phenotype”, and polarises gut-speci c immune responses mimicking the e ect of a diet low in fat and high in polysaccharides content.
8
1
12
Monica Di Paola, Elena Bonechi, Gustavo Provensi, Alessia Costa, Gerard Clarke, Clara Ballerini, Carlotta De Filippo , M. Beatrice Passani
File in questo prodotto:
File Dimensione Formato  
Paola_et_al-2018-Scientific_Reports.pdf

accesso aperto

Tipologia: Pdf editoriale (Version of record)
Licenza: Open Access
Dimensione 2.54 MB
Formato Adobe PDF
2.54 MB Adobe PDF Visualizza/Apri

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1136751
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 32
  • ???jsp.display-item.citation.isi??? 28
social impact