Introduction: The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide) contain primary sulfamoyl moieties acting as zinc-binding groups in the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). These drugs are widely used clinically and were recently shown to weakly inhibit isoforms CA I and II, but to possess stronger activity against isoforms involved in other important pathologies, for example, obesity, cancer, epilepsy and hypertension.
Diuretics with carbonic anhydrase inhibitory action: A patent and literature review (2005-2013) / Carta, Fabrizio; Supuran, Claudiu T. - In: EXPERT OPINION ON THERAPEUTIC PATENTS. - ISSN 1354-3776. - ELETTRONICO. - 23:(2013), pp. 681-691. [10.1517/13543776.2013.780598]
Diuretics with carbonic anhydrase inhibitory action: A patent and literature review (2005-2013)
Carta, FabrizioMembro del Collaboration Group
;Supuran, Claudiu TMembro del Collaboration Group
2013
Abstract
Introduction: The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide) contain primary sulfamoyl moieties acting as zinc-binding groups in the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). These drugs are widely used clinically and were recently shown to weakly inhibit isoforms CA I and II, but to possess stronger activity against isoforms involved in other important pathologies, for example, obesity, cancer, epilepsy and hypertension.File | Dimensione | Formato | |
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