Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.
CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY / SUPURAN CLAUDIU, DEDHAR SHOUKAT, CARTA FABRIZIO, WINUM JEAN-YVES, MCDONALD PAUL C. - (2010).
CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY
SUPURAN CLAUDIU;CARTA FABRIZIO;
2010
Abstract
Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.
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