Tissue-resident memory (Trm) cells are specialized components of both CD4+ and CD8+ T cell subsets that persist in peripheral non-lymphoid tissues following infections and provide fast response in case of a secondary invasion by the same pathogen. Trm cells express the surface markers CD69, CD103 and the immune checkpoint molecule PD-1. Trm cells develop not only in the context of infections but also in tumors, where they can provide a line of defense as suggested by the positive correlation between the frequency of tumor-infiltrating Trm cells and patients' survival. Trm cells persistence in peripheral tissues depends on their adaptation to the local microenvironment and the presence of survival factors, mainly IL-7, IL-15 and Notch ligands. However, the cell sources of these factors are largely unknown, especially in the context of tumors. Here we show that Head-Neck squamous cell carcinoma (HNSCC) is enriched in CD4+ and CD8+ T cells with a Trm phenotype. Moreover, we show that mesenchymal stromal cells that accumulate in HNSCC are a source of survival factors and allow proper expression of Trm-typical markers in a VCAM1-dependent manner. This article is protected by copyright. All rights reserved.

Human T cells interacting with HNSCC-derived mesenchymal stromal cells acquire Tissue-Resident memory like properties / Mazzoni, Alessio; Maggi, Laura; Montaini, Gianni; Ramazzotti, Matteo; Capone, Manuela; Vanni, Anna; Locatello, Luca Giovanni; Barra, Giusi; De Palma, Raffaele; Gallo, Oreste; Cosmi, Lorenzo; Liotta, Francesco; Annunziato, Francesco. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - STAMPA. - (2020), pp. 1571-1579. [10.1002/eji.202048544]

Human T cells interacting with HNSCC-derived mesenchymal stromal cells acquire Tissue-Resident memory like properties

Mazzoni, Alessio;Maggi, Laura;Montaini, Gianni;Ramazzotti, Matteo;Capone, Manuela;Vanni, Anna;Locatello, Luca Giovanni;Gallo, Oreste;Cosmi, Lorenzo;Liotta, Francesco;Annunziato, Francesco
2020

Abstract

Tissue-resident memory (Trm) cells are specialized components of both CD4+ and CD8+ T cell subsets that persist in peripheral non-lymphoid tissues following infections and provide fast response in case of a secondary invasion by the same pathogen. Trm cells express the surface markers CD69, CD103 and the immune checkpoint molecule PD-1. Trm cells develop not only in the context of infections but also in tumors, where they can provide a line of defense as suggested by the positive correlation between the frequency of tumor-infiltrating Trm cells and patients' survival. Trm cells persistence in peripheral tissues depends on their adaptation to the local microenvironment and the presence of survival factors, mainly IL-7, IL-15 and Notch ligands. However, the cell sources of these factors are largely unknown, especially in the context of tumors. Here we show that Head-Neck squamous cell carcinoma (HNSCC) is enriched in CD4+ and CD8+ T cells with a Trm phenotype. Moreover, we show that mesenchymal stromal cells that accumulate in HNSCC are a source of survival factors and allow proper expression of Trm-typical markers in a VCAM1-dependent manner. This article is protected by copyright. All rights reserved.
2020
1571
1579
Goal 3: Good health and well-being for people
Mazzoni, Alessio; Maggi, Laura; Montaini, Gianni; Ramazzotti, Matteo; Capone, Manuela; Vanni, Anna; Locatello, Luca Giovanni; Barra, Giusi; De Palma, Raffaele; Gallo, Oreste; Cosmi, Lorenzo; Liotta, Francesco; Annunziato, Francesco
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1195097
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