Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in CCA has not been explored. The aim of this study was to investigate the role of ERK5 in the biology of CCA.
Extracellular signal-regulated kinase 5 regulates the malignant phenotype of cholangiocarcinoma cells / Gentilini, A., Lori, G., Caligiuri, A., Raggi, C., Di Maira, G., Pastore, M., Piombanti, B., Lottini, T., Arcangeli, A., Madiai, S., Navari, N., Banales, J.M., Di Matteo, S., Alvaro, D., Duwe, L., Andersen, J.B., Tubita, A., Tusa, I., Di Tommaso, L., Campani, C., et al.. - In: HEPATOLOGY. - ISSN 0270-9139. - STAMPA. - (2021), pp. 1-10. [10.1002/hep.31888]
Extracellular signal-regulated kinase 5 regulates the malignant phenotype of cholangiocarcinoma cells
Gentilini, Alessandra;Lori, Giulia;Caligiuri, Alessandra;Raggi, Chiara;Di Maira, Giovanni;Pastore, Mirella;Piombanti, Benedetta;Lottini, Tiziano;Arcangeli, Annarosa;Madiai, Stefania;Navari, Nadia;Tubita, Alessandro;Tusa, Ignazia;Campani, Claudia;Rovida, Elisabetta;Marra, Fabio
2021
Abstract
Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in CCA has not been explored. The aim of this study was to investigate the role of ERK5 in the biology of CCA.
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