Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in CCA has not been explored. The aim of this study was to investigate the role of ERK5 in the biology of CCA.
Extracellular signal-regulated kinase 5 regulates the malignant phenotype of cholangiocarcinoma cells / Gentilini, Alessandra; Lori, Giulia; Caligiuri, Alessandra; Raggi, Chiara; Di Maira, Giovanni; Pastore, Mirella; Piombanti, Benedetta; Lottini, Tiziano; Arcangeli, Annarosa; Madiai, Stefania; Navari, Nadia; Banales, Jesus M; Di Matteo, Sabina; Alvaro, Domenico; Duwe, Lea; Andersen, Jesper B; Tubita, Alessandro; Tusa, Ignazia; Di Tommaso, Luca; Campani, Claudia; Rovida, Elisabetta; Marra, Fabio. - In: HEPATOLOGY. - ISSN 0270-9139. - STAMPA. - (2021), pp. 1-10. [10.1002/hep.31888]
Extracellular signal-regulated kinase 5 regulates the malignant phenotype of cholangiocarcinoma cells
Gentilini, Alessandra;Lori, Giulia;Caligiuri, Alessandra;Raggi, Chiara;Di Maira, Giovanni;Pastore, Mirella;Piombanti, Benedetta;Lottini, Tiziano;Arcangeli, Annarosa;Madiai, Stefania;Navari, Nadia;Tubita, Alessandro;Tusa, Ignazia;Campani, Claudia;Rovida, Elisabetta;Marra, Fabio
2021
Abstract
Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in CCA has not been explored. The aim of this study was to investigate the role of ERK5 in the biology of CCA.
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