We describe a method for the integration of high-throughput data from different sources. More specifically, iBATCGH is a package for the integrative analysis of transcriptomic and genomic data, based on a hierarchical Bayesian model. Through the specification of a measurement error model we relate the gene expression levels to latent copy number states which, in turn, are related to the observed surrogate CGH measurement via a hidden Markov model. Selection of relevant associations is performed employing variable selection priors that explicitly incorporate dependence information across adjacent copy number states. Posterior inference is carried out through Markov chain Monte Carlo techniques that efficiently explores the space of all possible associations. In this chapter we review the model and present the functions provided in iBATCGH, an R package based on a C implementation of the inferential algorithm. Lastly, we illustrate the method via a case study on ovarian cancer.

iBATCGH: Integrative Bayesian analysis of transcriptomic and CGH data / Cassese A.; Guindani M.; Vannucci M.. - STAMPA. - (2016), pp. 105-123. [10.1007/978-3-319-27099-9_6]

iBATCGH: Integrative Bayesian analysis of transcriptomic and CGH data

Cassese A.;Vannucci M.
2016

Abstract

We describe a method for the integration of high-throughput data from different sources. More specifically, iBATCGH is a package for the integrative analysis of transcriptomic and genomic data, based on a hierarchical Bayesian model. Through the specification of a measurement error model we relate the gene expression levels to latent copy number states which, in turn, are related to the observed surrogate CGH measurement via a hidden Markov model. Selection of relevant associations is performed employing variable selection priors that explicitly incorporate dependence information across adjacent copy number states. Posterior inference is carried out through Markov chain Monte Carlo techniques that efficiently explores the space of all possible associations. In this chapter we review the model and present the functions provided in iBATCGH, an R package based on a C implementation of the inferential algorithm. Lastly, we illustrate the method via a case study on ovarian cancer.
978-3-319-27097-5
978-3-319-27099-9
Statistical Analysis for High-Dimensional Data - The Abel Symposium 2014
105
123
Cassese A.; Guindani M.; Vannucci M.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1280503
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact