CARBAMOSELENOYL DERIVATIVES AS ANTI-INFECTIVE AGENTS

Compounds containing the carbamoselenoyl and/or sulfamoyl function, usable as selective antifungal agents against Malassezia pachydermatis strains for topical veterinary and human use, having the following general structures: Formula I; Formula II; Formula III; where X= C,N,O,S,Se or a Metal (M) R=H, SO2NHR, Alkyl, Alkylaryl, Halogen, Alkoxy, NO2, NNPR, Piperonyl, Naphthyl R2=H, alkyl, aryl, heteroaryl and designed to act through a dual action: a) the inhibition of the metal enzyme Carbonic Anhydrase (AC; EC 4.2.1.1) specifically expressed by Malassezia pachydermatis; b) the function as a carrier of the element selenium in organic form which is known to very effectively interfere with the metabolism and biosynthesis of lipid components of the target fungal organisms.