The role of adiponectin and other adipokines in eating disorders (in Handbook of the biology and pathology of mental disorders

The role of adipokines, particularly adiponectin, in feeding and eating disorders (FEDs) such as Anorexia Nervosa (AN), Bulimia Nervosa (BN), and Binge-Eating Disorder (BED) has garnered significant research attention. FEDs share a psychopathological core characterized by low self-esteem, over-evaluation of achievements, and intolerance of adverse mood states, all driving maladaptive body weight or shape influences. Adiponectin levels in patients with FED show distinct patterns: elevated in AN, variable in BN, and lower in BED, reflecting potential links to altered eating behavior and body weight regulation. This chapter synthesizes current literature to explore adiponectin, leptin and resistin involvement in FED pathophysiology, clinical presentation, and treatment implications. By identifying gaps in knowledge, it aims to provide a comprehensive overview and suggest avenues for future research and clinical application in understanding and managing FEDs.