Gangliosides, specifically GD2, contribute to cholan-giocarcinoma progression. Elevated GD2 expression,observed in 3D cultures, correlates with increased ag-gressiveness and drug resistance. Furthermore, GD2 upregulation promotes tumourgrowth in vivo. Overexpression of GD3 synthase(GD3S), the enzyme responsible for GD2 synthesis,mirrors these effects. These findings implicate both GD2 and GD3S as po-tential therapeutic targets in cholangiocarcinoma
Ganglioside GD2 Contributes to a Stem-Like Phenotype in Intrahepatic Cholangiocarcinoma / Antonella Mannini , Mirella Pastore , Alessia Giachi , Elena Spínola Lasso , Tiziano Lottini , Benedetta Piombanti , Ignazia Tusa , Elisabetta Rovida , Claudia Campani , Alessia Tani , Daniele Nosi , Anna Vanni , Laura Maggi , Giuseppina Comito , Stefania Madiai , Annarosa Arcangeli , Fabio Marra , Chiara Raggi. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - ELETTRONICO. - (2024), pp. 1-17.
Ganglioside GD2 Contributes to a Stem-Like Phenotype in Intrahepatic Cholangiocarcinoma
Antonella Mannini;Mirella Pastore;Alessia Giachi;Tiziano Lottini;Benedetta Piombanti;Ignazia Tusa;Elisabetta Rovida;Claudia Campani;Daniele Nosi;Anna Vanni;Laura Maggi;Giuseppina Comito;Stefania Madiai;Annarosa Arcangeli;Fabio Marra;Chiara Raggi
2024
Abstract
Gangliosides, specifically GD2, contribute to cholan-giocarcinoma progression. Elevated GD2 expression,observed in 3D cultures, correlates with increased ag-gressiveness and drug resistance. Furthermore, GD2 upregulation promotes tumourgrowth in vivo. Overexpression of GD3 synthase(GD3S), the enzyme responsible for GD2 synthesis,mirrors these effects. These findings implicate both GD2 and GD3S as po-tential therapeutic targets in cholangiocarcinoma
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
