Advances in Prodrugs: Design and Therapeutic Applications

One of the main current issue of drug-development is related to their unfavorable pharmacokinetic and pharmacodynamics due to their intrinsical physical-chemical properties. Medicinal chemists and pharmacologists needs to face these drug development-related problems. In this context, prodrugs offer an attractive approach to significantly improve pharmacokinetic and pharmacodynamics aspects. This book is intended to provide a comprehensive overview on the development of prodrugs and on their clinical applications, highlighting the most recent advances in the field. Focusing on both mechanistic and therapeutic aspects, this book aims to furnish medicinal chemists and pharmacologist with a useful guide for the design of novel prodrugs and for the development of new prodrug-based therapeutic approaches.